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Chemical Structure : STING PROTAC SP23
Catalog No.: PC-38566Not For Human Use, Lab Use Only.
SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.
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SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.
SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway.
| M.Wt | 699.677 | |
| Formula | C34H33N7O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jin Liu, et al. J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.1c01948.
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