Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Spautin-1
CAS No.: 1262888-28-7
Catalog No.: PC-62189Not For Human Use, Lab Use Only.
Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14.
Spautin-1 promotes cell death under starvation condition and inhibits autophagic cell death, selectively promotes the degradation of Vps34 complexes, reduces the levels of PtdIns3P in cells, but is not a direct inhibitor of class III PI3 kinase activity.
Spautin-1 promotes the degradation of p53 via inhibition of USP10, which can be inhibited in the presence of MG132.
Spautin-1 sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib).
| M.Wt | 271.271 | |
| Formula | C15H11F2N3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine |
|
1. Liu J, et al. Cell. 2011 Sep 30;147(1):223-34.
2. Li Y, et al. Nat Commun. 2017 Jun 1;8:15752. doi: 10.1038/ncomms15752.
3. Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21.
4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1;27(15):1718-30.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
