Chemical Structure : TAI-1
Catalog No.: PC-61481Not For Human Use, Lab Use Only.
A potent, small molecule Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=13.48 nM K562 cells).
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A potent, small molecule Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=13.48 nM K562 cells); displays 1,000 times improvement in potency compared to INH1, shows nM levels for the majority of the NCI-60 panel; targets the Hec1-Nek2 pathway, induces chromosomal misalignment and apoptosis, effectively inhibits tumor growth in multiple cancer xenograft models.
M.Wt | 431.51 | |
Formula | C24H21N3O3S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Huang LY, et al. J Exp Clin Cancer Res. 2014 Jan 9;33:6.
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