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Chemical Structure : TH9028
Catalog No.: PC-72939Not For Human Use, Lab Use Only.
TH9028 (TH-9028) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 11 nM.
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TH9028 (TH-9028) is a potent and selective inhibitor of folate metabolism enzyme MTHFD2 with IC50 of 11 nM.
TH9028demonstrated efficacy on HL-60 cell viability with EC50 of 11 nM.
TH9028 potently inhibits related MTHFD proteins MTHFD2L and MTHFD1-(DC) with IC50 of 47 and 16 nM, respectively.
| M.Wt | 458.399 | |
| Formula | C16H18N12O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nadilly Bonagas, et al. Nat Cancer. 2022 Feb;3(2):156-172.
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