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Chemical Structure : VX-745
CAS No.: 209410-46-8
Catalog No.: PC-42526Not For Human Use, Lab Use Only.
Neflamapimod (VX-745) is a potent and selective p38α kinase inhibitor with IC50 of 9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $288 | In stock | |
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| 100 mg | Get quote |
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Neflamapimod (VX-745) is a potent and selective p38α kinase inhibitor with IC50 of 9 nM.
Neflamapimod (VX-745) shows 20-fold selectivity for p38α over p38β (Ki=220 nM) and no significant inhibition for MAP kinases (with the exception of MKK6).
Neflamapimod (VX-745) exhibits inhibition of PBMC IL-1β and TNFα IC50 of 45 and 51 nM, respectively.
Neflamapimod (VX-745) possesses favorable PK profile, and demonstrates good in vivo activity in models of inflammation.
| M.Wt | 436.2621 | |
| Formula | C19H9Cl2F2N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 13.08 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
6H-Pyrimido[1,6-b]pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]- |
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1. Duffy JP, et al. ACS Med Chem Lett. 2011 Jul 28;2(10):758-63.
2. McGuire VA, et al. Mol Cell Biol. 2013 Nov;33(21):4152-65.
3. Alam JJ. J Alzheimers Dis. 2015;48(1):219-27.
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