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Chemical Structure : ZIKV inhibitor K22
Catalog No.: PC-35651Not For Human Use, Lab Use Only.
ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i).
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ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i).
ZIKV inhibitor K22 inhibits several members of the family Flaviviridae, blocks replication of ZIKV, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), as well as to a certain extent, Usutu virus (USUV), Wesselsbron virus (WESSV), HCV and bovine viral diarrhea virus (BVDV) with IC50s <10 uM.
ZIKV inhibitor K22 acts on early post-entry stages of coronavirus replication and to target membrane-bound viral RNA synthesis.
| M.Wt | 505.412 | |
| Formula | C27H25BrN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. García-Nicolás O, et al. Antimicrob Agents Chemother. 2018 Sep 4. pii: AAC.01206-18.
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