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Zavegepant

Chemical Structure : Zavegepant

CAS No.: 1337918-83-8

Zavegepant (BHV-3500, BMS-742413)

Catalog No.: PC-38690Not For Human Use, Lab Use Only.

Zavegepant (BHV-3500, BMS-742413)) is a high affinity, selective antagonist of calcitonin gene-related peptide (CGRP) receptor (hCGRP, Ki=0.023 nM), has demonstrated efficacy in the acute treatment of migraine.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Zavegepant (BHV-3500, BMS-742413)) is a high affinity, selective antagonist of calcitonin gene-related peptide (CGRP) receptor (hCGRP, Ki=0.023 nM), has demonstrated efficacy in the acute treatment of migraine.

Physicochemical Properties

M.Wt 638.817
Formula C36H46N8O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide

References

1. Stephen E Mercer, et al. Bioorg Med Chem Lett. 2021 Jan 1;31:127624.

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