| Cat. No. |
Product Name |
Information |
| PC-42484 |
GSK-690693
Akt inhibitor
|
GSK-690693 (GSK690693) is a potent, ATP competitive, pan-AKT inhibitor with IC50 of 2, 13, and 9 nM against AKT1, 2, and 3, respectively. |
| PC-42579 |
A-443654
Akt inhibitor
|
A-443654 is a potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1. |
| PC-42032 |
BAY-1125976
Akt inhibitor
|
BAY-1125976 is a potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18 nM at 10 uM ATP. |
| PC-45903 |
Perifosine
Akt inhibitor
|
Perifosine (KRX-0401, D21266) is an oral bioavailable alkylphospholipid, acts as an Akt inhibitor and a PI3K inhibitor, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway. |
| PC-42697 |
PF-AKT400
Akt inhibitor
|
PF-AKT400 is a broadly selective, potent, ATP-competitive Akt kinase inhibitor with IC50 of 0.5 nM (biochemical assay), and 0.31 nM (cell function assay). |
| PC-20556 |
AT13148
AGC kinase inhibitor
|
AT13148 (AT 13148) is a potent, ATP-competitive and orally active multi-AGC kinase inhibitor with IC50 vaules of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. |
| PC-49529 |
AZD5363
pan-AKT inhibitor
|
Capivasertib (AZD5363) is a potent, selective and orally bioavailable inhibitor of pan-Akt kinases with IC50 of <10 nM. |
| PC-38489 |
NSC 177223
Akt inhibitor
|
NSC 177227 (API-1) is a selective small molecule Akt/protein kinase B inhibitor, efficiently reduces the S473 phosphorylation levels of Akt with IC50 of 0.8 uM, binds to Akt PH domain and inhibits Akt membrane translocation. |
| PC-38375 |
Vevorisertib
pan-AKT inhibitor
|
Vevorisertib (MK-4440, ARQ 751) is a novel potent, selective, allosteric pan-AKT inhibitor with IC50 of 0.55 nM, 0.81 nM and 1.31 nM for AKT1, 2 and 3, respectively. |
| PC-73209 |
Miransertib free base
pan-Akt inhibitor
|
Miransertib free base (ARQ-092, MK-7075) is a potent, selective and allosteric pan-Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. |
| PC-73208 |
Miransertib
pan-Akt inhibitor
|
Miransertib (ARQ-092, MK-7075) is a potent, selective and allosteric pan-Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. |
