Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-38364	MCB-3681 Bactericidal antibiotic	MCB 3681 is a quinolonyl-oxazolidinone bactericidal antibiotic, has activity in vitro against Gram-positive bacteria. MCB3681 has a potent in vitro activity against C. difficile with MIC90 of 0.064 ug/ml.
PC-38363	LFF-571 Bactericidal antibiotic	LFF571 is a semisynthetic thiopeptide and bactericidal antibiotic that interferes with bacterial protein synthesis by inhibition of elongation factor EF-Tu, LFF571 is potent in vitro activity against C.difficile strains with MIC90 of 0.25 ug/mL.
PC-38362	MGB-BP-3 Bactericidal antibiotic	MGB-BP-3 is a potent bactericidal antibiotic with a completely novel mode of action, selectively binds to the minor grove of microbial DNA, has the potential for Clostridioides difficile infection (CDI).
PC-38361	Ibezapolstat DNA pol IIIC inhibitor	Ibezapolstat (ACX-362E) is a potent, selective, first-in-class DNA polymerase IIIC (DNA pol IIIC) inhibitor with IC50 of 51 nM (B. Subtilis pol IIIC), inhibits C. difficile efficiently (MIC50, 2 ug/mL).
PC-73349	PTC-672 Ng RNR inhibitor	PTC-672 (PTC672) is a novel orally active inhibitor that exhibits a narrow spectrum of activity against Neisseria gonorrhoeae (N. gonorrhoeae, Ng) including MDR isolates (MIC, 0.05 to 0.4 ug/mL), directly inhibits class Ia ribonucleotide reductase (RNR).
PC-73346	Xeruborbactam Beta-lactamase inhibitor	Xeruborbactam (QPX7728) is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).
PC-73194	AX20017 M.tb PknG inhibitor	AX20017 is a highly selective inhibitor of Mycobacterium tuberculosis protein kinase G (PknG) with IC50 of 0.39 uM.
PC-73144	Avibactam sodium Beta-lactamase inhibitor	Avibactam sodium (NXL104) is a novel β-lactamase inhibitor with a non-lactam structural scaffold, irreversibly inhibits lactamase from Mycobacterium tuberculosis.
PC-73118	Burkfloxacin Burkholderia inhibitor	Burkfloxacin (BFX) is a fluoroquinolone analog that potently inhibits growth of intracellular Burkholderia.
PC-72874	mCLB073 Rv1625c agonist	mCLB073 (mCLB 073) is a more potent, specific, oral small molecule agonist of the Mtb adenylyl cyclase Rv1625c, an optimized analog of the V-59 for in vivo use.
PC-72860	JCP276 Serine hydrolase inhibitor	JCP276 is a novel antibiotic and covalent inhibitor that disrupt M. tuberculosis growth by targeting multiple serine hydrolases.
PC-72815	MBL inhibitor 58 MBL inhibitor	MBL inhibitor 58 (InCs compound 58) is a potent broad-spectrum metallo-β-lactamase (MBL inhibitor), active against all MBL classes of major clinical relevance

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