| Cat. No. |
Product Name |
Information |
| PC-49791 |
OICR12694
Bcl-6 BTB inhibitor
|
OICR12694 (OICR 12694, JNJ-65234637) is a potent, selective, and orally bioavailable BCL6-BTB inhibitor with SPR KD value of 5 nM. |
| PC-49764 |
Venetoclax
Bcl-2 inhibitor
|
Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with Ki value of <0.01 nM. |
| PC-49189 |
DC-B01
BCL2 BH4 inhibitor
|
DC-B01 is a novel small molecule BCL-2 inhibitor that binds to the BH4 domain with KD of 2.16 uM, disrupts the BCL-2/c-Myc interaction and consequently suppresses the transcriptional activity of c-Myc. |
| PC-38807 |
CCT373566
BCL6 degarder
|
CCT373566 is a highly potent, in vivo active BCL6 degarder with IC50 of 2.2 nM and DC50 of 0.7 nM in TR-FRET and cellular BCL6 degradation assays, respectively. |
| PC-38806 |
CCT372064
BCL6 inhibitor
|
CCT372064 is a potent, ligand-efficient inhibitor of BCL6 with IC50 of 3.9 nM and 12 nM in TR-FRET and cellular NanoBRET assays, respectively. |
| PC-38660 |
GSK137
BCL6 inhibitor
|
GSK137 is a potent, small-molecule BCL6 inhibitor binding to BCL6 BTB-POZ domain, displaces peptides derived from the human SMRT co-repressor from the BCL6 BTB-POZ domain in a TR-FRET assay with a pIC50 of 8.0. |
| PC-38659 |
WK500B
BCL6 inhibitor
|
WK500B is an orally available small molecule BCL6 inhibitor with IC50 of 1.39 uM (HTFR), exhibits potent efficacy against DLBCL in vitro and in vivo. |
| PC-73235 |
ZH97
BFL-1 inhibitor
|
ZH97 is a selective and covalent small-molecule inhibitor of BFL-1 protein with binding Ki of 0.41 uM, >200-fold selectivity over MCL-1. |
| PC-73094 |
WEHI-9625
BAK inhibitor
|
WEHI-9625 (WEHI9625) is a small molecule selectively binds to VDAC2 and promotes its ability to inhibits apoptosis (EC50=69 nM) driven by murine BAK. |
| PC-72519 |
CCT369347
BCL-6 inhibitor
|
CCT369347 (CCT-369347) is potent selective inhibitor of BCL-6 with TR-FRET IC50 of 26 nM. |
| PC-42836 |
TW-37
|
TW-37 is a potent, nonpeptidic small-molecule inhibitor of Bcl-2 with Ki of 290 nM, also binds to Bcl-xL and Mcl-1 with high affinities. |
| PC-42826 |
HA14-1
|
HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells. |
