| Cat. No. |
Product Name |
Information |
| PC-62743 |
MI-223
|
MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents. |
| PC-62306 |
A 385358
|
A 385358 is a potent, selective, cell-permeable Bcl-XL inhibitor with Ki of 0.8 nM, displays >80-fold selectivity over Bcl-2 (Ki=64 nM). |
| PC-61991 |
BM-957
|
BM-957 is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively. |
| PC-61990 |
BM-1197
|
BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1. |
| PC-61989 |
S44563
|
S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively. |
| PC-61017 |
BCL6 inhibitor 7
|
A potent BCL6 protein-protein interaction inhibitor with Kd of 78 nM. |
| PC-61016 |
BCL6 inhibitor 8c
|
A novel potent, in vivo-active BCL6 inhibitor with IC50 of 0.1 uM in ELISA assays. |
| PC-60153 |
Mcl1-IN-26
|
A novel potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays. |
| PC-42125 |
BH3I-1
|
A small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay. |
| PC-45041 |
MIM1
|
A potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1. |
| PC-42756 |
Obatoclax
|
A potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1. |
| PC-45490 |
UMI-77
|
A potent and selective Mcl-1 inhibitor with Ki of 0.49 uM. |
