| Cat. No. |
Product Name |
Information |
| PC-63255 |
SJ830599
|
SJ830599 is a modest selective BRD2-BD2 inhibitor with IC50 of 0.61 uM, 3.3-fold selectivity over BRD2-BD1. |
| PC-63245 |
Y08060
|
Y08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1, displays excellent selectivity for BET subfamily over other non-BET family with the exception of moderate inhibition of CBP/EP300. |
| PC-43414 |
I-BET151
BET inhibitor
|
I-BET151 (GSK1210151A) is a potent, selective BET bromodomain inhibitor with IC50 of 0.5, 0.25 and 0.79 uM for BRD2, BRD3 and BRD4 in FP assays, shows no effect on the 23 other bromodomain proteins including MLL. |
| PC-43341 |
GSK525768A
|
GSK525768A is an enantiomer, negative control compound of I-BET762 (GSK525762A), shows no activity against BET family proteins BRD2, BRD3 and BRD4.. |
| PC-43340 |
I-BET762
BET inhibitor
|
I-BET762 (GSK-525762A, Molibresib) is a highly potent, selective inhibitor of BET family proteins BRD2, BRD3 and BRD4 with IC50 of 32.5-42.5 nM, does not interact with other bromodomain-containing proteins (BAZ2B, ATAD2, CREBBP and PCAF). |
| PC-63219 |
TRIM24 inhibitor X
TRIM24 inhibitor
|
TRIM24 inhibitor X is a potent TRIM24 bromodomain inhibitor for synthesis dTRIM24.. |
| PC-63218 |
IACS-7e
TRIM24 inhibitor
|
IACS-7e is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement). |
| PC-63216 |
IACS-9571
TRIM24 inhibitor
|
IACS-9571 is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively. |
| PC-43027 |
BET-BAY 002
BET inhibitor
|
BET-BAY 002 is a potent BET bromodomain inhibitor, shows efficacy in a multiple myeloma model. |
| PC-43338 |
JQ1
|
(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively. |
| PC-62986 |
AZD-5153
|
AZD-5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM. |
| PC-62938 |
BRD9-IN-28
BRD9/BRD7 inhibitor
|
BRD9-IN-28 is a highly potent and selective BRD7/9 bromodomain inhibitor with pIC50 of 6.9, Kd of 68 nM for BRD9. |
