| Cat. No. |
Product Name |
Information |
| PC-20566 |
Apcin-A
APC inhibitor
|
Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor, interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. |
| PC-20494 |
Cdk5i peptide
Cdk5/p25 inhibitor
|
Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone. |
| PC-20345 |
Cdc25A inhibitor 7h
|
Cdc25A inhibitor 7h is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
| PC-20344 |
Cdc25A inhibitor 7g
|
Cdc25A inhibitor 7g is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
| PC-20315 |
LGR6768
CDK7 inhibitor
|
LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs. |
| PC-20284 |
QR-6401
CDK2 inhibitor
|
QR-6401 (QR6401) is a highly potent, selective, oral macrocyclic CDK2 inhibitor. |
| PC-20283 |
PF-07104091
CDK2 inhibitor
|
PF-07104091 (PF 07104091) is a highly potent CDK2-selective inhibitor with potential for the treatment of cyclinE-amplified cancers. |
| PC-49792 |
CDKL5/GSK3 inhibitor 2
CDKL5 inhibitor
|
CDKL5/GSK3 inhibitor 2 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively. |
| PC-49787 |
BMS-357075
pan CDK inhibitor
|
BMS-357075 is a potent pan inhibitor of cyclin-dependent kinases (CDKs) with IC50 of 18, 3 and 26 nM for CDK1, CDK2, and CDK4, respectively, also inhibits CDK20 with Kd of 56 nM. |
| PC-49786 |
MER-128
CDK20 inhibitor
|
MER-128 is a potent, selective CDK20 inhibitor with IC50 of 2 nM. |
| PC-49698 |
EF-4-177
CDK2 inhibitor
|
EF-4-177 is a potent, selective, allosteric and orally active CDK2 inhibitor with ITC KD of 7.4 nM.
EF-4-177 binds CDK2 in a manner that is negatively cooperative with cyclin binding. |
| PC-49444 |
MK256
CDK8 inhibitor
|
MK256 (MK-256) is a potent, selective CDK8 inhibitor with IC50 of 2.5 nM and 3.3 nM against CDK8/cyclin C and CDK19/cyclin C, respectively. |
