| Cat. No. |
Product Name |
Information |
| PC-42425 |
Senexin B
CDK8/CDK19 inhibitor
|
Senexin B (SNX2-1-165) is a highly potent, selective and orally available CDK8/CDK19 inhibitor with IC50 of 24-50 nM. |
| PC-42527 |
JNJ-7706621
CDK/Aurora inhibitor
|
JNJ-7706621 is a potent, dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively. |
| PC-22118 |
AZD8421
CDK2 inhibitor
|
AZD8421 (AZD-8421) is a potent, highly selective CDK2 inhibitor with IC50 of 9 nM, >300-fold selectivity over CDK9. |
| PC-22032 |
KY-273
CDK8/19 inhibitor
|
KY-273 (KY273) is a potent, specific CDK8/19 inhibitor with IC50 of 29.1 and 44.7 nM respectively, promotes osteoblast differentiation and has cortical-bone-selective osteogenic effects. |
| PC-21964 |
dCeMM4
Cyclin K degrader
|
dCeMM4 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. |
| PC-21963 |
dCeMM3
Cyclin K degrader
|
dCeMM3 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. |
| PC-21962 |
dCeMM2
Cyclin K degrader
|
dCeMM2 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. |
| PC-21922 |
LDC3140
CDK7 inhibitor
|
LDC3140 is a potent, selective CDK7 inhibitor with IC50 of <5 nM, >500-fold selective over CDK1/2/4/6/9. |
| PC-21886 |
CVT-313
CDK2 inhibitor
|
CVT-313 (CVT313) is a potent, specific CDK2 inhibitor with IC50 of 0.5 uM (CDK2/cyclin A), equally inhibits CDK2/cyclin E. |
| PC-21703 |
CP681301
CDK5 inhibitor
|
CP681301 is a potent, highly specific CDK5 inhibitor, completely inhibits both CDK5-P35 and CDK5-P25 at 1 uM. |
| PC-21681 |
XPW1
CDK9 inhibitor
|
XPW1 is a potent and selective CDK9 inhibitor with excellent anti-ccRCC activity and low toxicity. |
| PC-21562 |
GFH009
CDK9 inhibitor
|
GFH009 is a potent, selective CDK9 inhibitor, inhibits the activity of the CDK9/cyclin T1 regulatory complex of P-TEFb. |
