Cat. No. |
Product Name |
Information |
PC-38692 |
FT709
USP9X inhibitor
|
FT709 is a potent, highly selective USP9X inhibitor with IC50 of 82 nM in biochemical assays, reduces CEP55 expression in BxPC3 pancreatic cancer cells with IC50 of 131 nM. |
PC-73355 |
Subquinocin
CYLD inhibitor
|
Subquinocin is a small molecule inhibitor of DUB activity of CYLD with IC50 of 30 uM, enhances NF-κB activation by inhibiting CYLD. |
PC-72836 |
NJH-2-075
OTUB1 recruiter DUBTAC
|
NJH-2-075 is an alkyne-functionalized probe of EN523, retains binding to OTUB1 in vitro. |
PC-72835 |
EN523
OTUB1 recruiter DUBTAC
|
EN523 (EN-523) is a small molecule covalent ligand that targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1, OTUB1 recruiter component of DUBTAC NJH-2-057. |
PC-72699 |
MT16-001
UCHL1 inhibitor
|
MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM). |
PC-72535 |
HBX-90659
USP8 inhibitor
|
HBX-90659 (compound 22 e) is a potent, selective USP8 inhibitor with IC50 of 0.28 uM, with no effect on USP7 (IC50 of >100 uM). |
PC-72253 |
FT385
USP30 inhibitor
|
FT385 (FT3967385) is a potent, selective USP30 inhibitor with biochemical IC50 of 1.5 nM. |
PC-72252 |
USP30 inhibitor Compound 39
USP30 inhibitor
|
USP30 inhibitor Compound 39 (CMPD-39) is a highly selective inhibitor of USP30 with IC50 of 20 nM in an in vitro assay of enzyme activity, >100-fold selectivity over other DUBs. |
PC-38192 |
USP7-866
USP7 inhibitor
|
USP7-866 is a novel potent selective inhibitor of USP7 with IC50 of 0.18 nM. |
PC-38191 |
USP7-797
USP7 inhibitor
|
USP7-797 is a novel potent selective inhibitor of USP7 with IC50 of 0.44 nM. |
PC-38173 |
FT206
USP28 inhibitor
|
FT206 (FT-206, FT3951206, CRT0511973) is a potent, selectivel inhibitor of USP28 with a remarkable USP28/25 selectivity. |
PC-38156 |
XL-9872-106C
JOSD1/USP30/UCHL1 inhibitor
|
XL-9872-106C (XL-106C) is a potent, selective inhibitor of the deubiquitinase (DUB) JOSD1/USP30/UCHL1 with IC50 of 134/390/166 nM, respectively. |