| Cat. No. |
Product Name |
Information |
| PC-21634 |
Cbl-b inhibitor 3
Cbl-b inhibitor
|
Cbl-b inhibitor 3 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b with IC50 of 5.5 nM in Cbl-b LCK Ub TR-FRET assays. |
| PC-21633 |
Cbl-b inhibitor 2
Cbl-b inhibitor
|
Cbl-b inhibitor 2 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b. |
| PC-21632 |
Cbl-b inhibitor 1
Cbl-b inhibitor
|
Cbl-b inhibitor 1 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b. |
| PC-21631 |
Cbl-b inhibitor 25
Cbl-b inhibitor
|
Cbl-b inhibitor 25 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b with IC50 of 15 nM in TR-FRET assays. |
| PC-21046 |
KLHDC2 E3 ubiquitin ligase ligand 1
KLHDC2 E3 ligand
|
KLHDC2 E3 ubiquitin ligase ligand 1 is a 7 aa C-terminal fragment of the SelK protein used for PROTAC degradation. |
| PC-38766 |
EN106 derivative 3
E3 Ligase Ligand
|
EN106 derivative 3 is a EN106 derivative used for PROTAC design, EN106 is a covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation. |
| PC-38765 |
EN106 derivative 2
E3 Ligase Ligand
|
EN106 derivative 2 is a EN106 derivative used for PROTAC design, EN106 is a covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation. |
| PC-38764 |
EN106 derivative 1
E3 Ligase Ligand
|
EN106 derivative 1 is a EN106 derivative used for PROTAC design, EN106 is a covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation. |
| PC-38760 |
EN106
FEM1B ligand
|
EN106 is a cysteine-reactive covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation, PROTAC linking EN106 to the BET bromodomain inhibitor JQ1 or the kinase inhibitor dasatinib leads to the degradation of BRD4 and BCR-ABL, respectively. |
| PC-38610 |
VL285
E3 Ligase Ligand
|
VL285 is a potent VHL ligand that degrades HaloTag7 fusion proteins, attenuates the ability of HaloPROTAC3 to induce the degradation of GFP-HaloTag7 (IC50=0.34 uM). |
| PC-38591 |
BTX306
Protein homeostatic modulator
|
BTX306 (BTX-306) is a novel protein homeostatic modulator, potently reduces levels of GSPT1, eRF1, CK1α, MCL-1, and c-MYC in myeloma cells, overcomes bortezomib and lenalidomide resistance. |
| PC-38389 |
Eragidomide
CRBN E3 ligase modulator
|
Eragidomide (CC-90009) is a first-in-class, GSPT1-selective cereblon E3 ligase modulator, selectively degrades GSPT1 (EC50=9 nM) resulting in acute AML apoptosis and elimination of disease-driving leukemia stem cells (LSCs). |
