| Cat. No. |
Product Name |
Information |
| PC-21766 |
Smurf1 inhibitor A01
Smurf1 inhibitor
|
Smurf1 inhibitor A01 is a specific small molecule inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) with Kd of 3.66 nM for interrupting Smurf1-Smad1 interaction, impairs Smurf1-mediated Smad1/5 degradation and stabilizes Smad1/5 protein level. |
| PC-21555 |
C7683
Cbl-b inhibitor
|
C7683 is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC5 of <1 nM, an analogue of Nx-1607. |
| PC-21396 |
SMIP004
Skp2 inhibitor
|
SMIP004 is a small molecule inducer of cancer-cell selective apoptosis and S-phase kinase-associated protein 2 (Skp2) inhibitor, shows anti-cancer and antidepressant-like activities. |
| PC-21374 |
Nimbolide
RNF114 inhibitor
|
Nimbolide is a natural product derived from the Neem tree, inhibits E3 ligase activity of RNF114, blocks PARP1 degradation and causes PARP1 trapping. |
| PC-21307 |
Smurf1 inhibitor 1
SMURF1 inhibitor
|
Smurf1 inhibitor 1 is a potent, selective Smurf1 E3 ligase inhibitor with IC50 of 230 nM in in UbFluor assays, inhibits the catalytic HECT domain of Smurf1. |
| PC-21056 |
Skp2-2
Skp2-Cks1 inhibitor
|
Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells. |
| PC-20919 |
SMURF1 inhibitor 29
SMURF1 inhibitor
|
SMURF1 inhibitor 29 is a potent, specific E3 ubiquitin protein ligase 1 (SMURF1) inhibitor with biochemical IC50 of 11 nM, displays no activity against SMURF2. |
| PC-20904 |
SMURF1 inhibitor 38
SMURF1 inhibitor
|
SMURF1 inhibitor 38 is a potent, specific E3 ubiquitin protein ligase 1 (SMURF1) inhibitor with biochemical IC50 of 92 nM, displays no activity against SMURF2. |
| PC-20550 |
T0467
PINK1-Parkin activator
|
T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1. |
| PC-20317 |
BC1464
FBXO7 inhibitor
|
BC1464 (BC 1464) is a small molecule inhibitor of ubiquitin E3 ligase receptor component FBXO7, efficiently decreases the interaction between FBXO7 and PINK1, increases cellular PINK1 concentrations and activities. |
| PC-20113 |
PELI1-EGFR inhibitor S62
PELI1/EGFR inhibitor
|
PELI1-EGFR inhibitor S62 is a small molecule inhibitor of the interaction between PELI1 and EGFR, suppresses breast cancer metastasis. |
| PC-49510 |
NAB2
Nedd4 inhibitor
|
NAB2 (Nedd4 inhibitor NAB2) is a specific small molecule inhibitor of E3 ubiquitin ligase Nedd4 with binding KD of 42 nM. |
