Cat. No. |
Product Name |
Information |
PC-20976 |
BMS-986318
FXR agonist
|
BMS-986318 is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 53 nM in FXR Gal4 luciferase reporter assays. |
PC-20485 |
BAR502
Dual FXR/GPBAR1 agonist
|
BAR502 (NorECDCOH) is a potent, selective, dual farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligand (agonist) with EC50 of 2.0 and 0.4 uM, respectively. |
PC-20484 |
PDL103
Dual FXR/GPBAR1 antagonist
|
PDL103 is a potent, dual FXR/GPBAR1 antagonist with IC50 of 10 and 19 uM, respectively. |
PC-20460 |
INT-767
FXR/TGR5 agonist
|
INT-767 is a potent, dual farnesoid X receptor (FXR)/TGR5 agonist with EC50s of 30 and 630 nM, respectively. |
PC-47028 |
BMS-986339
FXR agonist
|
BMS-986339 is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 34 nM (hFXR-Gal4), demonstrates differential induction of Fgf15 in the liver and ileum by FXR agonists in vivo. |
PC-43034 |
INT-767
|
INT-767 is a potent, selective, dual farnesoid X receptor (FXR) and TGR5 agonist with EC50 of 30 and 630 nM, respectively. |
PC-63021 |
MFA-1
|
MFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays, displays 500-fold more potent than CDCA. |
PC-42734 |
Fexaramine
|
A potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064. |
PC-45980 |
Chenodeoxycholic Acid
|
A potent natural bile acid at stimulating the nuclear bile acid receptor, farnesoid X receptor (FXR). |
PC-45904 |
WAY-362450
|
A highly potent, selective, and orally active agonist of FXR with EC50 of 4 nM. |