| Cat. No. |
Product Name |
Information |
| PC-20172 |
BAY 87-2243
Mitochondrial complex I inhibitor
|
BAY 87-2243 (BAY87-2243) is a highly potent, selective inhibitor of hypoxia-induced gene activation (IC50=0.7 nM), directly inhibits mitochondrial complex I. |
| PC-49790 |
GSK1120360A
HIF-PHD inhibitor
|
GSK1120360A (GSK360A) is a potent, specific and orally active inhibitor of HIF PHD enzyme with pIC50 of 8.0/7.0/6.9 for PHD1/2/3, respectively. |
| PC-49374 |
ISCA2 inhibitor 25
ISCA2 inhibitor
|
ISCA2 inhibitor 25 is a selective, orally available small molecule inhibitor of HIF-2α with IC50 of 0.92 uM, decrease HIF-1/2α levels and induce ferroptosis by targeting Iron Sulfur Cluster Assembly 2 (ISCA2), a component of the late mitochondrial Iron Sulfur Cluster (L-ISC) assembly complex. |
| PC-72532 |
YQ-0629
HIF-2α inhibitor
|
YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM. |
| PC-72330 |
HIF inhibitor 208
HIF inhibitor
|
HIF inhibitor 208 is a small molecule inhibitor of HIF pathway with IC50 of 0.5 nM. |
| PC-38033 |
HIF-2α-IN-2
|
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor with IC50 of 16 nM in scintillation proximity assay, extracted from patent WO2015035223A1, Compound 232.. |
| PC-35912 |
KCN1
|
KCN1 (HIF inhibitor KCN1) is a small molecule inhibitor of the HIF-1 pathway, antagonizes HIF transcription in bioassay, blocks the p300/HIF-1α interaction, and exert potent anticancer activity in vitro and in vivo. |
| PC-35269 |
IOX4
|
IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM, displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases. |
| PC-63449 |
TP-0463518
|
TP-0463518 is a novel, highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively. |
| PC-43267 |
PT2385
|
PT2385 (PT-2385) is a potent, selective, and orally active antagonist of HIF2α, binds to HIF2α PAS-B domain (Kd=50 nM) and disrupts HIF2α/ARNT dimer formation. |
| PC-43241 |
JNJ-42041935
|
JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively. |
| PC-43179 |
ML228
|
ML228 (ML-228, CID-46742353) is an activator of the hypoxia inducible factor (HIF) pathway with EC50 of 1.4 uM in HIF-1α nuclear translocation assays. |
