| Cat. No. |
Product Name |
Information |
| PC-20826 |
TX-1918
HIV-1 capsid inhibitor
|
TX-1918 (TX1918) is a specific inhibitor of HIV-1 capsid assembly taregting the C-terminal domain of HIV-1 capsid (CA CTD) with IC50 of 3.81 uM, inhibits viral replication (EC50=15.16 μM) and inhibits CA assembly in vitro. |
| PC-20513 |
BDM2
IN-LEDGF/p75 inhibitor
|
BDM2 is a potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor (INLAI), shows potent anti-HIV activity. |
| PC-49723 |
GSK878
HIV-1 Capsid inhibitor
|
GSK-878 (GSK878) is a highly potent, long-acting inhibitor targeting the HIV-1 capsid with picomolar potency against HIV-1 infection in vitro (EC50=39 pM). |
| PC-49592 |
YIR-819
CD4 Mimetic
|
YIR-819 is a small molecule that inhibits the protein-protein interaction between gp120 and CD4, exhibits potent anti-HIV activity with IC50 of 2.6 uM. |
| PC-49590 |
YIR-821
CD4 Mimetic
|
YIR-821 is a small molecule that inhibits the protein-protein interaction between gp120 and CD4, exhibits potent anti-HIV activity with IC50 of 2.8 uM. |
| PC-49515 |
GSK1264
HIV-1 integrase inhibitor
|
GSK1264 is an allosteric inhibitor of HIV-1 integrase, disrupts the interaction between HIV-1 integrase (IN) and the cellular factor LEDGF/p75 with IC50 of 8.2 nM, inhibits HIV-1 replication with IC50 of 38 nM. |
| PC-47033 |
VTD227
HIV-1 Vpr inhibitor
|
VTD227 is a small molecule Vpr-targeting HIV-1 inhibitor, directly binds to Vpr with Kd of 8.8 uM, inhibits HIV-1 replication in monocyte-derived macrophages (MDM) with IC50 of 0.78 uM. |
| PC-38800 |
JX-7
NNRTI
|
JX-7 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) with remarkable inhibitory activity against wild-type HIV-1 (EC50=5 nM) and numerous clinically observed variants in MT-4 cells. |
| PC-38744 |
Emivirine
HIV-1 RT inhibitor
|
Emivirine (MKC-442) is a highly potent and selective inhibitor of HIV-1 reverse transcriptase (RT) with IC50 of 8 nM, does not inhibit HIV-1 RNase H, other RTs, or DNA polymerase alpha. |
| PC-38643 |
GSK3839919
HIV-1 integrase inhibitor
|
GSK3839919 is a potent, allosteric HIV-1 integrase inhibitor (ALLINI). |
| PC-38594 |
BRD-K98645985
BAF inhibitor
|
BRD-K98645985 is a small molecule inhibitor of BAF (mammalian SWI/SNF)-mediated transcription with EC5 of 2.37 uM, binds ARID1A-specific BAF complexes, reverses HIV-1 latency in vitro and ex vivo. |
| PC-38556 |
Q308
Latent HIV-1 inhibitor
|
Q308 is a small molecule that silences the latent HIV-1 provirus by inhibiting Tat-mediated gene transcription and selectively downregulates the expression levels of the facilitated chromatin transcription (FACT) complex. |
