| Cat. No. |
Product Name |
Information |
| PC-62566 |
MAL3-101
|
MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM. |
| PC-62516 |
KUNB 31
|
KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM, displays 50-fold selectivity over Hsp90α and Grp94. |
| PC-62493 |
HS-131
|
HS-131 is an imaging probe of Hsp90 activity by linking it to a near-infrared (nIR) dye, HS131 uptake into cells correlated with cell membrane expression of Hsp90 and was used to image molecular subtypes of murine and human breast cancers in vitro and in murine models.. |
| PC-62469 |
YK5
|
YK5 is a small molecule inhibitor of Hsp70 and Hsc70, induces the degradation of HER2, Raf-1, and Akt kinases, also induces apoptosis in the SKBr3 breast cancer cells.. |
| PC-62198 |
YM-1
|
YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM. |
| PC-61905 |
Epolactaene
|
Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells. |
| PC-61797 |
NSC 145366
|
NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM. |
| PC-61633 |
CCT-018159
|
CCT-01815 is a novel potent inhibitor of Hsp90 ATPase activity with IC50 of 7.1 uM. |
| PC-61302 |
HSF1A
|
A small molecule human HSF1 (heat shock transcription factor 1) activator. |
| PC-70363 |
A-17
|
A potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1. |
| PC-70362 |
CP-9
|
A potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM. |
| PC-60670 |
PF 04942847
|
An orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM. |
