Cat. No. |
Product Name |
Information |
PC-42321 |
EED226
PRC2 inhibitor
|
EED226 (EED 226) is a potent, selective, orally bioavailable PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED (IC50=22 nM). |
PC-45115 |
EPZ-011989 trifluoroacetate
EZH2 inhibitor
|
EPZ-011989 trifluoroacetate is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM. |
PC-45114 |
EPZ-011989
EZH2 inhibitor
|
EPZ-011989 (EPZ011989) is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM. |
PC-42097 |
EPZ-015866
PRMT5 inhibitor
|
EPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM. |
PC-42198 |
SGC-2085
CARM1 inhibitor
|
SGC-2085 is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM). |
PC-42081 |
A-196
SUV420H2 inhibitor
|
A-196 is a potent, selective and substrate-competitive inhibitor of protein lysine methyltransferases (PKMTs) SUV420H1 and SUV420H2 with IC50 of 25 nM and 144 nM, respectively. |
PC-45598 |
LLY-507
SMYD2 inhibitor
|
LLY-507 is a potent, selective and cell-active inhibitor of SMYD2 (IC50<15 nM). |
PC-45092 |
MI-503
Menin-MLL inhibitor
|
MI-503 (MI 503) is a highly potent and orally bioavailable small-molecule inhibitor of Menin-MLL interaction with Kd of 9.3 nM. |
PC-42907 |
3-Deazaneplanocin A hydrochloride
EZH2 inhibitor
|
3-Deazaneplanocin A (DZNep) hydrochloride is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2. |
PC-42587 |
3-Deazaneplanocin A
EZH2 inhibitor
|
3-Deazaneplanocin A (DZNep) is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2. |
PC-42923 |
MM-102 trifluoroacetate
MLL1/WDR5 inhibitor
|
MM-102 trifluoroacetate is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM. |
PC-42922 |
MM-102
MLL1/WDR5 inhibitor
|
MM-102 is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM. |