| Cat. No. |
Product Name |
Information |
| PC-42198 |
SGC-2085
CARM1 inhibitor
|
SGC-2085 is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM). |
| PC-42081 |
A-196
SUV420H2 inhibitor
|
A-196 is a potent, selective and substrate-competitive inhibitor of protein lysine methyltransferases (PKMTs) SUV420H1 and SUV420H2 with IC50 of 25 nM and 144 nM, respectively. |
| PC-45598 |
LLY-507
SMYD2 inhibitor
|
LLY-507 is a potent, selective and cell-active inhibitor of SMYD2 (IC50<15 nM). |
| PC-42037 |
HLCL-61 hydrochloride
PRMT5 inhibitor
|
HLCL-61 hydrochloride is a potent and selective protein arginine methyltransferase PRMT5 inhibitor. |
| PC-45092 |
MI-503
Menin-MLL inhibitor
|
MI-503 (MI 503) is a highly potent and orally bioavailable small-molecule inhibitor of Menin-MLL interaction with Kd of 9.3 nM. |
| PC-42907 |
3-Deazaneplanocin A hydrochloride
EZH2 inhibitor
|
3-Deazaneplanocin A (DZNep) hydrochloride is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2. |
| PC-42587 |
3-Deazaneplanocin A
EZH2 inhibitor
|
3-Deazaneplanocin A (DZNep) is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2. |
| PC-42923 |
MM-102 trifluoroacetate
MLL1/WDR5 inhibitor
|
MM-102 trifluoroacetate is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM. |
| PC-42922 |
MM-102
MLL1/WDR5 inhibitor
|
MM-102 is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM. |
| PC-22135 |
AMG193
PRMT5 inhibitor
|
AMG193 (AMG-193) is a potent, selective and MTA-cooperative PRMT5 inhibitor, exhibits selective antitumor activity in MTAP-null cancer models. |
| PC-22134 |
TNG462
PRMT5 inhibitor
|
TNG462 (TNG-462) is a potent, selective, MTA-cooperative PRMT5 inhibitor, selective inhibits MTAP-deleted cancer cell lines. |
| PC-22132 |
TNG908
PRMT5 inhibitor
|
TNG908 (TNG-908) is a potent, selective, brain penetrant, MTA-cooperative PRMT5 inhibitor with IC50 of 9 nM in SDMA in-cell western assay, binds the PRMT5·MTA complex, selectively kills MTAP-deleted (MTAP-null) cells. |
