| Cat. No. |
Product Name |
Information |
| PC-22119 |
ORIC-944
PRC2 inhibitor
|
ORIC-944 (ORIC944) is a potent, selective, allosteric and orally bioavailable PRC2 inhibitor with EED binding EC50 of 106 pM and biochemical PRC2 EC50 of 16.7 nM. |
| PC-22053 |
MS8535
SPIN1 inhibitor
|
MS8535 is a potent, selective and cell-active inhibitor of methyl-lysine reader protein SPIN1 with biochemical IC50 of 202 nM and ITC binding Kd of 30 nM. |
| PC-21974 |
Bleximenib oxalate
menin-MLL inhibitor
|
Bleximenib oxalate is a potent, selective menin/MLL protein/protein interaction inhibitor, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes. |
| PC-21973 |
Bleximenib
menin-MLL inhibitor
|
Bleximenib is a potent, selective menin/MLL protein/protein interaction inhibitor, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.
|
| PC-21951 |
EPZ005687
EZH2 inhibitor
|
EPZ005687 is a potent, selective and SAM-competitive inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity over EZH1 and 500-fold selectivity against 15 other protein methyltransferases. |
| PC-21950 |
GSK343
EZH2 inhibitor
|
GSK343 is a highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitor with IC50 of 4 nM and Kiapp of 1.2 nM. |
| PC-21940 |
UNC1999
EZH2 inhibitor
|
UNC1999 is a potent, selectice SAM-competitive and orally bioavailable inhibitor of EZH2/EZH1 with IC50 of <10 nM/45 nM, respectively. |
| PC-21939 |
GSK126
EZH2 inhibitor
|
GSK126 (GSK2816126A) is a potent, highly selective, and SAM-competitive inhibitor of EZH2 methyltransferase with IC50 of 9.9 nM. |
| PC-21938 |
Tazemetostat
EZH2 inhibitor
|
Tazemetostat (EPZ-6438) is a potent, selective, SMA-competitive and orally available EZH2 inhibitor with IC50 of 11 and 16 nM in peptide assay and nucleosome assay, respectively. |
| PC-21930 |
CPI-360
EZH2 inhibitor
|
CPI-360 is a potent, selective EZH2 inhibitor with IC50 of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively. |
| PC-21857 |
BI-9321 trihydrochloride
NSD3 inhibitor
|
BI-9321 (BI 9321) trihydrochloride is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM. |
| PC-21842 |
GSK3368715 dihydrochloride
Type 1 PRMT inhibitor
|
GSK3368715 (EPZ019997, GSK-3368715) dihydrochloride is a potent, reversible and SAM uncompetitive type I PRMT inhibitor with Kiapp of 1.5 to 81 nM for PRMT1, 3, 4, 6, and 8. |
