| Cat. No. |
Product Name |
Information |
| PC-20135 |
UZH1a
METTL3 inhibitor
|
UZH1a is a potent, selective and cell‐permeable inhibitor of METTL3 with IC50 of 0.28 uM, 100-fold more potent than enantiomer UZH1b. |
| PC-20124 |
DC-PRC2in-01
EZH2-EED inhibitor
|
DC-PRC2in-01 is a small molecule PRC2 inhibitor targeting EZH2-EED interaction with affinity Kd of 4.56 uM, decreases global H3K27me3 levels in cancer cells. |
| PC-20003 |
XY1
|
XY1 is the inactive control compound of SGC707, which is a potent selective PRMT3 inhibitor. |
| PC-49814 |
SMYD3 inhibitor 49
SMYD3 inhibitor
|
SMYD3 inhibitor 49 is a potent and selective SMYD3 inhibitor with IC50 of 6.3 and 44 nM in biochemical and cellular MEKK2me assays, respectively. |
| PC-49729 |
BRD9539
G9a inhibitor
|
BRD9539 is a small molecule inhibitor of histone hethyltransferase of G9a (euchromatin histone methyltransferase 2, EHMT2) with IC50 of 6.3 uM. |
| PC-49728 |
UNC0642
G9a/GLP inhibitor
|
UNC0642 (UNC 0642) is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor with IC50 of <2.5 nM. |
| PC-49699 |
SKLB-03220
EZH2 inhibitor
|
SKLB-03220 (SKLB03220) is a potent, selective EZH2 covalent inhibitor with IC50 of 1.72 nM (EZH2 WT). |
| PC-49683 |
CDIBA
METTL3-14 inhibitor
|
CDIBA is an allosteric inhibitors of m6A-RNA methyltransferase, METTL3 -14 complex with IC50 of 17.3 uM, also reported as a cytosolic phospholipase A2 (cPLA2) inhibitor. |
| PC-49674 |
IHMT-337
EZH2 inhibitor
|
IHMT-337 (IHMT337) is a potent, highly selective and irreversible EZH2 inhibitor, specifically inhibits the methylation at H3K27. |
| PC-49612 |
RK-701
G9a/GLP inhibitor
|
RK-701 (RK701) is a potent, highly selective and reversible histone lysine methyltransferases G9a and G9a-like protein (GLP) inhibitor with IC50 of 23-27 nM and 53 nM, respectively. |
| PC-49598 |
WDR5 inhibitor 10
WDR5 inhibitor
|
WDR5 inhibitor 10 is a highly potent, selective and orally active inhibitor of WD repeat domain 5 (WDR5) with TR-FRET Ki value of <0.02 nM, shows potent antiproliferative activity with GI50 of 9.7 nM in MV4:11 cells. |
| PC-49506 |
WDR5 WIN site inhibitor 16
WDR5 inhibitor
|
WDR5 WIN site inhibitor 16 is a potent, selective inhibitor of WD repeat domain 5 (WDR5) WIN site with TR-FRET Kd of <0.02 nM, exhibits histone methyltransferase inhibition with IC50 of 2.2 nM. |
