| Cat. No. |
Product Name |
Information |
| PC-38602 |
MI-3
menin-MLL inhibitor
|
MI-3 is a potent inhibitor of the interaction between menin-MLL with IC50 of 648 nM, binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells without affecting protein levels of menin or MLL-AF9. |
| PC-38521 |
WDR5 inhibitor 41
WDR5 inhibitor
|
WDR5 inhibitor 41 is a potent, selective and orally bioavailable WDR5 WIN-site inhibitor with TR-FRET Ki value of <0.02 nM, inhibits cell proliferation of MV4:11 and MOLM-13 with IC50 of 13 and 27 nM, respectively. |
| PC-73099 |
SKI-73
CARM1 inhibitor
|
SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors. |
| PC-72717 |
NAH-C3-GPKK
NTMT1/KMT9 inhibitor
|
NAH-C3-GPKK is a potent, selective protein N-terminal methyltransferase 1 (NTMT1) bisubstrate inhibitor with Kiapp of 7 nM in endogenous proteomes. |
| PC-72716 |
Compound II757
pan-PRMT inhibitor
|
Compound II757 (II757) is a potent, cell-active pan-PRMT inhibitor with IC50 of 5-555 nM for eight PRMTs, with the highest inhibition for PRMT4 (IC50=5 nM). |
| PC-72494 |
ASH1L inhibitor AS-99
ASH1L inhibitor
|
ASH1L inhibitor AS-99 (AS-99) is a first-in-class, potent, selective inhibitor of ASH1L histone methyltransferase with IC50 of 0.79 uM. |
| PC-72468 |
AH237
PRMT4/5 inhibitor
|
AH237 (AH-237) is a potent and selective inhibitor for PRMT4 and PRMT5 with IC50 of 2.8 and 0.42 nM, respectively. |
| PC-72396 |
SGC3027N
PRMT7 inhibitor
|
SGC3027N (SGC-3027N) is a negative control compound for SGC3027, shows markedly less potent (14 uM) against PRMT7 and other protein methyltransferases. |
| PC-72366 |
TDI-11904
EZH2 inhibitor
|
TDI-11904 is a highly potent, and peripherally active EZH2 inhibitor. |
| PC-72365 |
TDI-6118
EZH2 inhibitor
|
TDI-6118 is a potent, selective brain-penetrant EZH2 inhibitor with IC50 of 14 nM, inhibits cellular H3K27me with IC50 of 580 nM. |
| PC-72317 |
EPZ-719
SETD2 inhibitor
|
EPZ-719 (EPZ 719) is a potent, selective SETD2 histone methyltransferase inhibitor with IC50 of 8 nM. |
| PC-72295 |
SW2_152F
CBX2 inhibitor
|
SW2_152F (SW2 152F) is a potent, selective, cell permeable CBX2 chromodomain probe, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM. |
