Cat. No. |
Product Name |
Information |
PC-49209 |
UNC6934
NSD2-PWWP1 inhibitor
|
UNC6934 is a potent, selective chemical probe ligand targeting the N-terminal PWWP (PWWP1) domain of NSD2 with Kd value of 91 nM, selectively binds in the aromatic cage of NSD2-PWWP1, thereby disrupting its interaction with H3K36me2 nucleosomes. |
PC-49020 |
TC-E 5003
PRMT1 inhibitor
|
TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9. |
PC-47080 |
MS8511
G9a/GLP inhibitor
|
MS8511 is a first-in-class G9a/GLP covalent, irreversible inhibitor with IC50 of 100/140 nM respectively, displays improved potency in enzymatic and cellular assays compare with noncovalent G9a/GLP inhibitor UNC0642. |
PC-38535 |
SGC2085 hydrochloride
CARM1 inhibitor
|
SGC-2085 hydrochloride is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM). |
PC-73451 |
Tulmimetostat
EZH2 inhibitor
|
Tulmimetostat (CPI-0209) is a potent, selective, second-generation EZH2 inhibitor for the treatment of cancers. |
PC-73322 |
EZM0414
SETD2 inhibitor
|
EZM 0414 is a potent, selective and orally bioavailable inhibitor of histone methyltransferase SETD2 with biochemical IC50 of 18 nM, >10,000-fold selectivity over other HMTases. |
PC-73122 |
MRK-740
PRDM9 inhibitor
|
MRK-740 (MRK740) is a first-in-class, potent, selective and cell-active PRDM9 inhibitor with IC50 of 80 nM. |
PC-73067 |
BR-001
PRC2 EED inhibitor
|
BR-001 (BR001) is a potent, selective, allosteric inhibitor of EED subunit of PRC2 complex, disrupts EED-H3K27me3 interaction (IC50=4.5 nM). |
PC-73054 |
PFI-5
SMYD2 inhibitor
|
PFI-5 a highly biochemically potent, selective, and cell-active SMYD2 chemical probe with IC50 of 8 nM. |
PC-73027 |
SPIN1 inhibitor MS31
SPIN1 inhibitor
|
SPIN1 inhibitor MS31 (MS31) is a potent, selective, and cell-active inhibitor of methyllysine reader protein SPIN1 (spindlin 1) with IC50 of 77 nM. |
PC-72992 |
SMYD3 inhibitor 29
SMYD3 inhibitor
|
SMYD3 inhibitor 29 is a highly potent, selective, covalent inhibitor of histone methyltransferase SMYD3 with IC50 of 1.7 nM. |
PC-72793 |
SNDX5613
menin-MLL inhibitor
|
Revumenib (SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with Ki of 0.149 nM. |