| Cat. No. |
Product Name |
Information |
| PC-72394 |
SGC3027
PRMT7 inhibitor
|
SGC3027 (SGC-3027) is the cell permeable prodrug of SGC8158, a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM. |
| PC-72393 |
MRTX1719
PRMT5 inhibitor
|
MRTX1719 (MRTX-1719) is a potent, selective binder to the PRMT5-MTA complex, selectively inhibits PRMT5 activity in MTAP-deleted cells (HCT116 MTAP-deleted IC50=12 nM) compared to MTAP-wild-type cells. |
| PC-72299 |
NSD1 inhibitor BT5
NSD1 inhibitor
|
NSD1 inhibitor BT5 is a covalent, small molecule inhibitor of NSD1 histone methyltransferase with IC50 of 1.4 uM, shows no covalent binding to NSD2. |
| PC-72292 |
MR837
NSD2-PWWP1 inhibitor
|
MR837 (NSD2-PWWP1 inhibitor 3f) is a small-molecule antagonist (inhibitor) that binds to the NSD2-PWWP1 domain (SPR Kd=3.4 uM, NSD2 IC50=17.3 uM), abrogates histone H3K36me2 binding to the PWWP1 domain in cells. |
| PC-72045 |
F5446
SUV39H1 inhibitor
|
F5446 (F 5446) is a specific small molecule inhibitor of H3K9me3-specific histone methyltransferase SUV39H1 with EC50 of 0.496 uM in an in vitro enzymatic activity assay. |
| PC-38300 |
MS1943
EZH2 degrader
|
MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM. |
| PC-38218 |
BAY-155
menin-MLL inhibitor
|
BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503. |
| PC-38209 |
DC541
NTMT1 inhibitor
|
DC541 (DC 541) is a potent, selective peptidomimetic inhibitor of Protein N-terminal methyltransferase NTMT1 with IC50 of 0.34 uM. |
| PC-38151 |
SHIN1
SHMT1/2 inhibitor
|
SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM. |
| PC-38150 |
SHIN2
SHMT1/2 inhibitor
|
SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1. |
| PC-38010 |
MU1656
DOT1L inhibitor
|
MU1656 (MU 1656 ) is a potent, highly selective inhibitor of histone methyltransferase DOT1L with IC50 of 2 nM. |
| PC-36119 |
WDR5 WIN site inhibitor C6
WDR5 inhibitor
|
WDR5 inhibitor C6 is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM. |
