| Cat. No. |
Product Name |
Information |
| PC-60508 |
Delgocitinib
JAK inhibitor
|
Delgocitinib (JTE-052, LEO 124249) is a potent, selective, orally active, pan-JAK inhibitor with IC50 of 2.8, 2.6, 13 and 58 nM for JAK1,2,3 and Tyk2, respectively. |
| PC-60314 |
PF-956980
JAK3 inhibitor
|
PF-956980 is a potent, highly specific JAK3 inhibitor with IC50 of 4 nM. |
| PC-60312 |
PF-06263276
pan-JAK inhibitor
|
PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
| PC-45653 |
Upadacitinib
JAK1 inhibitor
|
Upadacitinib (ABT-494) is a potent and selective JAK1 inhibitor with celluar IC50 of 8 nM, biochemical IC50 of 40 nM. |
| PC-45652 |
Peficitinib
JAK inhibitor
|
Peficitinib (ASP-015K, JNJ-54781532) is a potent JAK inhibitor with IC50s of 3.9 and 0.7 nM for JAK1 and JAK3 respectively. |
| PC-45664 |
NS-018 hydrochloride
|
NS-018 hydrochloride (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM). |
| PC-45663 |
NS-018
|
NS-018 (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM). |
| PC-45662 |
NS-018 maleate
|
NS-018 maleate (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM). |
| PC-45816 |
Tofacitinib
|
Tofacitinib (CP-690550) is a potent, specific, orally active inhibitor of JAK3 with IC50 of 1 nM in cell-free assays. |
| PC-45872 |
Ruxolitinib
JAK1/2 inhibitor
|
Ruxolitinib (INCB-018424) is a potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively. |
| PC-42569 |
TG-101348
JAK2 inhibitor
|
TG-101348 (Fedratinib, SAR302503) is a potent, selective JAK2 inhibitor with IC50 of 3 nM for both wt JAK2 and JAK2 V617F. |
| PC-44040 |
NVP-BSK805 dihydrochloride
JAK2 inhibitor
|
NVP-BSK805 dihydrochloride is a potent, selective and ATP-competitive inhibitor of JAK2 (V617F) and wt JAK2 (IC50=0.5 nM). |
