| Cat. No. |
Product Name |
Information |
| PC-21298 |
RLY-2608
PI3Kα H1047R inhibitor
|
RLY-2608 (RLY2608) is a first-in-class, allosteric, mutant-selective inhibitor of PI3Kα with IC50 of 4 nM (PI3Kα H1047R), 12-fold selective over PI3Kα WT. |
| PC-21139 |
STX-478
PI3Kα H1047R inhibitor
|
STX-478 (STX478) is a potent, mutant-selective, allosteric PI3Kα inhibitor with IC50 of 9.4 nM (PI3Kα H1047R), 14-fold selectivity over WT PI3Kα (IC50=131 nM). |
| PC-20848 |
UCL-TRO-1938
PI3Kα activator
|
UCL-TRO-1938 (Compound 1938) is a selective, allosteric activator of PI3Kα with EC50 of 60 uM (based on in vitro lipid kinase activity), directly activates PI3Kα signalling in cells. |
| PC-20591 |
IOA-244
PI3Kδ inhibitor
|
IOA-244 (Roginolisib, MSC2360844) is a potent, selective and non-ATP-competitive PI3Kδ inhibitor with IC50 of 19 nM, selective over PI3Kβ (0.43 uM), Vps34 (9 uM) and PI3Kα (10.1 uM). |
| PC-20374 |
I-229
Vps34 inhibitor
|
I-229 is a potent and selective inhibitor of Vps34. |
| PC-49531 |
LL-00084282
PI3Kδγ inhibitor
|
LL-00084282 is a potent, selective and efficacious dual PI3Kδγ inhibitor with IC50 of 16.26 and 17.45 nM for PI3Kδ and PI3Kγ, respectively. |
| PC-49341 |
PITCOIN3
PI3KC2α inhibitor
|
PITCOIN3 is a potent, highly selective, cell-permeable inhibitor of PI3KC2α catalytic activity with IC50 of 126 nM. |
| PC-49141 |
CUDC-907
HDAC/PI3K inhibitor
|
Fimepinostat (CUDC-907) is a potent, dual-acting PI3K and HDAC inhibitor, potently inhibits HDAC classes I and II enzymes, inhibits class I PI3K kinases with IC50 of 19, 54, and 39 nM for PI3Kα, PI3Kβ, and PI3Kδ, respectively. |
| PC-49022 |
PF-06862309
PI3Kα inhibitor
|
PF-06862309 (PF-06843195 phosphate ester prodrug) is the in vivo-active, phosphate ester prodrug of PF-06843195, a potent selective PI3Kα inhibitor with Kd of <18 pM. |
| PC-49021 |
PF-06843195
PI3Kα inhibitor
|
PF-06843195 is a potent, selective PI3Kα inhibitor with Ki value of <0.018 nM, IC50 of 18 nM (RAT1 PI3Kα), with cellular isoform selectivity of 20-fold over PI3Kβ and 9-fold over PI3Kδ. |
| PC-73424 |
Izorlisib
PI3K inhibitor
|
Izorlisib (MEN1611, CH5132799) is a potent, selective, orally available class I PI3K inhibitor with IC50 of 14/120/400/36 nM against PI3Kα/β/δ/γ, respectively. |
| PC-38318 |
CPL302-253
PI3Kδ inhibitor
|
CPL302-253 is a potent, selective inhibitor of PI3Kδ with IC50 of 12.2 nM and Kd of 0.83 nM, >350-fold selectivity over PI3K isoforms α, β, and γ (IC50>4,500 nM). |
