| Cat. No. |
Product Name |
Information |
| PC-20453 |
TGX286
p110β inhibitor
|
TGX286 is a potent, selective p110β inhibitor with IC50 of 7, 17 and 13 nM for p110β WT, p110β D862Q, and p110β E858H, respectively, >100-fold selectivity over p110α. |
| PC-20451 |
PITCOIN2
PI3KC2α inhibitor
|
PITCOIN2 (LU-06-006) is a potent selective PI3KC2α inhibitor with IC50 of 126 nM, has selectivity against PI3KC2γ but shows micromolar activity on PI3KC2β. |
| PC-20375 |
VPS34 inhibitor 5
|
VPS34 inhibitor 5 is a potent, selective, and orally bioavailable VPS34 inhibitor with IC50 of 83 nM, >95-fold selectivity over other PIK family kinases. |
| PC-20008 |
cyclo-CRVLIR
p110α/RAS inhibitor
|
cyclo-CRVLIR is a cyclic peptide that binds selectively to p110α RAS binding domain (p110α-RBD) with ITC Kd of 3 uM, blocks p110α/RAS interaction in vitro and KRAS cancer cell lines. |
| PC-49266 |
LP-182
PI3K inhibitor
|
LP-182 (LP182) is a potent, selective and orally bioavailable multi-functional kinase inhibitor, specifically targets PI3K and MAPK signaling pathways. |
| PC-38789 |
LL-00071210
PI3Kδ inhibitor
|
LL-00071210 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 values of 24.6 nM and 9.4 nM in biochemical and cellular assays, respectively. |
| PC-38687 |
HM5023507
PI3Kδ/γ inhibitor
|
HM5023507 is a potemt, selective, orally active dual PI3Kδ/γ inhibitor with IC50 of 4 nM and 5 nM for p110γ and p110δ, respectively. |
| PC-38686 |
AZD8154
PI3Kδ/γ inhibitor
|
AZD8154 is a highly potent, selective dual PI3Kγ/δ inhibitor with cell pIC50 of 9.1/8.4, respectively. |
| PC-38635 |
NVP-CLR457
class I PI3K inhibitor
|
NVP-CLR457 (CLR457) is a potent, orally bioavailable, non-CNS-penetrant pan-class I PI3K inhibitor with IC50 values of 89 nM, 56 nM, 39 nM and 230 nM for p110α, p110β, p110δ and p110γ isoforms, respectively. |
| PC-38383 |
Amdizalisib
PI3Kδ inhibitor
|
Amdizalisib (HMPL-689) is a highly selective and potent oral inhibitor of phosphoinositide 3-kinase-delta (PI3Kδ) with potential antineoplastic activity. |
| PC-73420 |
Gilmelisib
PI3K inhibitor
|
Gilmelisib is a potent PI3K inhibitor with IC50 of <1 nM for PI3K p110α, exhibits antineoplastic acitvity. |
| PC-73277 |
PQR514
PI3K inhibitor
|
PQR514 is a potent selective pan-PI3K inhibitor with binding Ki of 2.2 and 33 nM for p110α and mTOR, repectively. |
