| Cat. No. |
Product Name |
Information |
| PC-42513 |
Omipalisib
PI3K/mTOR inhibitor
|
Omipalisib (GSK2126458) is a highly potent dual inhibitor PI3K/mTOR inhibitor with app Ki of 19/130/24/60/180/300 nM for p110α/p110β/p110γ/p110δ/mTORC1/mTORC2 respectively. |
| PC-42133 |
PF-04979064
PI3K/mTOR inhibitor
|
PF-04979064 is a highly potent and selective, dual PI3K/mTOR inhibitor with Ki of 0.13, 0.111, 0.122 and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ and mTOR, respectively. |
| PC-42310 |
LY294002
PI3K inhibitor
|
LY294002 is a classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively. |
| PC-22175 |
KTC1101
pan-PI3K inhibitor
|
KTC1101 is a potent, selective pan-PI3K inhibitor with IC50 of 3.72 nM for PI3Kα, 36.29 nM for PI3Kβ, 1.22 nM for PI3Kδ, and 17.09 nM for PI3Kγ. |
| PC-22090 |
QR-7909
PI3Kα H1047R inhibitor
|
QR-7909 is a potent, specific and allosteric PI3Kα H1047R inhibitor with IC50 of 51 nM, 27-fold selective over WT PI3Kα in biochemical assays. |
| PC-21948 |
PIK-108
p110β inhibitor
|
PIK-108 is a potent, selective and allosteric PI3K p110β inhibitor with IC50 of 57 nM, 45-fold selective over PI3Kα (IC50=2600 nM). |
| PC-21947 |
PI3Kα H1047R inhibitor 17
H1047R PI3Kα inhibitor
|
PI3Kα H1047R inhibitor 17 is a potent, selective H1047R PI3Kα mutant inhibitor with IC50 of 1 nM (inhibition of pAKT formation), without effect on PI3Kα WT. |
| PC-21944 |
GSK2636771
PI3Kβ inhibitor
|
GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with Ki/IC50 of 0.89/5.2 nM, respectively. |
| PC-20590 |
Alpelisib
PI3Kα inhibitor
|
Alpelisib (NVP-BYL719, BYL719) is ia potent, selective, and orally active PI3Kα inhibitor with IC50 of 5 nM, >50-fold selectivity over p110γ/p110δ/p110β. |
| PC-20568 |
Zandelisib
p110δ inhibitor
|
Zandelisib (ME-401, PWT-143) is a potent, selective and orally active inhibitor of phosphatidylinositol 3 kinase p110δ with IC50 of 3.5 nM. |
| PC-20534 |
Copanlisib
PI3K inhibitor
|
Copanlisib (BAY 80-6946) is a potent, highly selective pan-class I PI3K inhibitor with IC50 of 0.5, 3.7, 6.4, and 0.7 nM for PI3Kα, β, γ, and δ isoforms, respectively. |
| PC-20468 |
PI3Kβ inhibitor (P)-14
|
PI3Kβ inhibitor (P)-14 is a potent, highly selective and orally bioavailable PI3Kβ inhibitor with IC50 of 2 nM. |
