| Cat. No. |
Product Name |
Information |
| PC-72644 |
CFT-2718
BRD4 degrader
|
CFT-2718 (CFT2718) is a benzotriazoloazepine-based BRD4 degrader, rapidly and selectively degrade BRD4 in vitro in a CRBN-dependent manner (DC90=10 nM, 293T cells). |
| PC-72621 |
ARV-471
ER degrader
|
ARV-471 (Vepdegestrant) is an investigational orally bioavailable PROTAC protein degrader designed to specifically target and degrade the estrogen receptor (ER) with DC50 of 1.8 nM. |
| PC-72572 |
SR-1114
ENL degarder
|
SR-1114 (SR1114) is a first-in-class ENL PROTAC degarder based on SR-0813 that binds to the E3 substrate adapter cereblon (CRBN), elicits rapid CRBN-dependent degradation of ENL with DC50 of 150 nM in MV4;11 cells. |
| PC-72309 |
DGY-09-192
FGFR degrader
|
DGY-09-192 is a bivalent degrader (PROTAC) that couples the pan-FGFR inhibitor BGJ398 to a CRL2VHL E3 ligase recruiting ligand,preferentially induces FGFR1/2 degradation while largely sparing FGFR3/4. |
| PC-72308 |
HPK1 PROTAC SS47
HPK1 degrader
|
HPK1 PROTAC SS47 is a heterobifunctional small molecule based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1. |
| PC-72307 |
HPK1 PROTAC SS44
HPK1 degrader
|
HPK1 PROTAC SS44 is a heterobifunctional small molecule HPK1 PROTAC degrader based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1. |
| PC-38303 |
Helios degrader ALV2
Helios degrader
|
Helios degrader ALV2 (ALV-04-019-01) is a potent and selective Helios degrader with IC50 of 0.57 uM in CRBN-binding TR-FRET assay. |
| PC-38302 |
Helios degrader ALV1
Helios degrader
|
Helios degrader ALV1 (ALV-03-112-01) is a small molecule degrader of the zinc-finger transcription factor Helios with IC50 of 0.55 uM in CRBN-binding TR-FRET assay. |
| PC-38232 |
DDC-01-163
EGFR PROTAC
|
DDC-01-163 is an allosteric EGFR degrader that selectively inhibit the proliferation of L858R/T790M (L/T) mutant Ba/F3 cells while leaving wildtype EGFR Ba/F3 cells unaffected. |
| PC-38185 |
SHP2-D26
SHP2 PROTAC
|
SHP2-D26 is a potent and effective SHP2 degrader (PROTAC) with DC50 of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4. |
| PC-38182 |
SHP2 PROTAC R1-5C
SHP2 PROTAC
|
SHP2 PROTAC R1-5C is a potent and highly selective SHP2 PROTAC created by conjugating RMC-4550 with pomalidomide using a PEG linker, with a low nanomolar DC50. |
| PC-38058 |
BSJ-4-116
CDK12 degrader
|
BSJ-4-116 is a potent, CDK12 specific degrader (PROTAC) with IC50 of 6 nM, exhibits anti-proliferative activity in cancer cells. |
