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Cat. No. Product Name Information
PC-38182

SHP2 PROTAC R1-5C

SHP2 PROTAC

SHP2 PROTAC R1-5C is a potent and highly selective SHP2 PROTAC created by conjugating RMC-4550 with pomalidomide using a PEG linker, with a low nanomolar DC50.
PC-38058

BSJ-4-116

CDK12 degrader

BSJ-4-116 is a potent, CDK12 specific degrader (PROTAC) with IC50 of 6 nM, exhibits anti-proliferative activity in cancer cells.
PC-38054

DT2216

BCL-XL PROTAC

DT2216 (DT-2216) is a specific BCL-XL PROTAC by linking ABT263 to a VHL ligand (VHL-L), induces BCL-XL degradation in MOLT-4 T-ALL cells with DC50 of 63 nM.
PC-38047

Bavdegalutamide

AR degrader

Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR with DC50 of <1 nM.
PC-38019

dCBP-1

p300/CBP PROTAC

dCBP-1 is a potent, selective chemical degrader of p300/CBP based on PROTAC.
PC-36151

NRX-252114

NRX-252114 (NRX 252114, NRX252114) is a potent, small molecule β-TrCP-based degrader of β-catenin, potentiates pSer33/S37A β-catenin binding and ubiquitylation (EC50=6.5 nM).
PC-35936

BSJ-03-123

CDK6 PROTAC

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions.
PC-35882

VZ185

BRD9 PROTAC

VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively.
PC-35859

FKBP12 PROTAC dTAG-13

FKBP12 degrader

FKBP12 PROTAC dTAG-13 (dTAG-13) is an in vivo-active heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells.
PC-35858

FKBP12 PROTAC dTAG-7

FKBP12 degrader

FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells.
PC-35668

GSK983

PCAF/GCN5 PROTAC

GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively.
PC-35667

GSK699

PCAF/GCN5 PROTAC

GSK699 (GSK-699) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells.

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