| Cat. No. |
Product Name |
Information |
| PC-35151 |
TL13-12
ALK PROTAC
|
TL13-12 is a novel Anaplastic Lymphoma Kinase (ALK)-PROTAC developed through conjugation of TAE684 and the cereblon ligand pomalidomide. |
| PC-63465 |
JH-XI-10-02
CDK8 PROTAC
|
JH-XI-10-02 is a CDK8 PROTAC based on the CDK8 inhibitor JH-VIII-49, induces partial degradation of CDK8 in Jurkat cells with IC50 of 159 nM.. |
| PC-63217 |
dTRIM24
TRIM24 PROTAC
|
dTRIM24 is a potent and selective, bifunctional PROTAC degrader of TRIM24 with IC50 of 337.7 nM in TRIM24 ligand displacement assay. |
| PC-60330 |
THAL-SNS-032
CDK9 PROTAC
|
THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). |
| PC-60234 |
CCT-367766
Pirin degrader
|
CCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells.. |
| PC-60126 |
dBRD9
BRD9 PROTAC
|
dBRD9 is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells. |
| PC-60102 |
BETd-260
BET PROTAC
|
BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60099 |
MZ1
BRD4 PROTAC
|
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers and induces degradation of the BET bromodomain BRD4. |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-22174 |
MS181
PRC1 degrader
|
MS181 is a first-in-class CRBN-recruiting and EED-binding (Kd=190 nM) polycomb repressive complex 1 (PRC1) degrader, preferentially degrades PRC1 components BMI1 and RING1B over PRC2 components EZH2 and SUZ12. |
| PC-22157 |
MS8709
G9a/GLP degrader
|
MS8709 is a potent, selective first-in-class G9a/GLP proteolysis targeting chimera (PROTAC) degrader with DC50 of 274/260 nM in 22Rv1 cells, respectively. |
