| Cat. No. |
Product Name |
Information |
| PC-62661 |
GSK-872
RIPK3 inhibitor
|
GSK-872 (GSK'872) is a potent and selective RIPK3 (receptor-interacting protein kinase-3) inhibitor with IC50 of 1.3 nM, inhibits RIPK3-mediated necroptosis. |
| PC-60549 |
GSK-963
RIPK1 inhibitor
|
GSK-963 (GSK963) is a potent and selective inhibitor of RIP1 kinase (RIPK1) with IC50 of 29 nM in FP binding assays. |
| PC-70204 |
Sibiriline
RIPK1 inhibitor
|
Sibiriline is a specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3. |
| PC-42439 |
YM-155
Survivin inhibitor
|
YM-155 is a potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM, targets RIPK2 kinase activity. |
| PC-42102 |
GSK-583
RIPK2 inhibitor
|
GSK-583 is a potent, selective and orally bioavailable RIPK2 kinase inhibitor with IC50 of 5 nM and 2 nM for human and rat RIP2, respectively. |
| PC-45564 |
WEHI-345
RIPK2 inhibitor
|
WEHI-345 is a potent and selective RIPK2 inhibitor with IC50/Kd of 130/46 nM. |
| PC-42301 |
RIPA-56
RIPK1 inhibitor
|
RIPA-56 is a highly potent, selective, stable Receptor-interacting protein 1 (RIPK1) inhibitor with IC50 of 13 nM. |
| PC-42065 |
GSK-481
RIPK1 inhibitor
|
GSK-481 (GSK481) is a highly potent, monokinase selective and ATP-competitive inhibitor of RIP1 kinase (RIPK1) with biochemical IC50 of 10 nM. |
| PC-21707 |
RIPK1 inhibitor 62
RIPK1 inhibitor
|
RIPK1 inhibitor 62 is a potent, selective, orally bioavailable type-II kinase inhibitor of RIPK1 with IC50 of 3.5 nM (hRIPK1), 200-fold less potent against hRIPK3. |
| PC-21572 |
AC-003
RIPK1 inhibitor
|
AC-003 is a novel oral small-molecule inhibitor of receptor interacting protein kinase 1(RIPK1) and has the potential for treating idiopathic pulmonary fibrosis. |
| PC-21082 |
Zharp2-1
RIPK2 inhibitor
|
Zharp2-1 is a novel potent, selective RIPK2 inhibitor with IC50 of 38.5 nM in ADP-Glo kinase assay, effectively blocks RIPK2 kinase function and NOD-mediated NF-κB/MAPK activation. |
| PC-20562 |
aYM155
YM155 prodrug
|
aYM155 is a brain-penetrating prodrug form of YM155 (Cat. PC-42439, potent survivin inhibitor), displays potent cell killing activity against a broad panel of patient-derived GBM cancer stem-like cells (IC50=0.7-10 nM). |
