Cat. No. |
Product Name |
Information |
PC-20878 |
BI-2493
pan-KRAS inhibitor
|
BI-2493 is a structural analogue of BI-2865 for in vivo administration, BI-2493 a potent, inactive state selective, non-covalent pan KRAS inhibitor. |
PC-20877 |
BI-2865
pan-KRAS inhibitor
|
BI-2865 is a potent, inactive state selective, non-covalent pan KRAS inhibitor, binds to the GDP-loaded state of WT, G12C, G12D, G12V and G13D KRAS with high affinity (ITC Kd values,10-40 nM), inactivates common cancer-causing KRAS mutants. |
PC-20608 |
RMC-6291
KRAS G12C inhibitor
|
RMC-6291 (RMC6291) is a potent, covalent, next-generation, mutant-selective inhibitor of active state KRAS G12C(ON) with IC50 of 0.7 nM (pERK), RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). |
PC-49406 |
BI-0474
KRAS G12C inhibitor
|
BI-0474 (BI 0474) is a potent, in vivo active KRAS G12C inhibitor with IC50 of 7.0 nM in GDP-KRAS::SOS1 protein-protein interaction assay. |
PC-38549 |
AZD4625
KRAS G12C inhibitor
|
AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM. |
PC-38438 |
MRTX-EX185
KRAS G12D inhibitor
|
MRTX-EX185 (EX185) is a novel potent small-molecule inhibitor of KRAS mutants, exhibits target engagement against KRAS (G12D) with IC50 of 90 nM, binds to GDP-loaded KRAS and KRAS(G12D), as well as the active GNP state. |
PC-73419 |
Garsorasib
KRas-G12C inhibitor
|
Garsorasib (D-1553) is a potent, selective, orally bioavailable and covalent KRas-G12C inhibitor with IC50 of 10 nM, exhibits potent anti-tumor activity in a broad spectrum of tumor cell lines. |
PC-73367 |
DW0254
PDE6D-RAS inhibitor
|
DW0254 (DW-0254) is a small molecules capable of inhibiting RAS-related C3 botulinum toxin substrate (RAC) small GTPase activation in ALL cell lines, directly binds to the hydrophobic pocket of PDE6D (Kd=436 nM, ITC), a RAS chaperone protein. |
PC-73323 |
GDC-6036
KRAS G12C inhibitor
|
GDC-6036 (Divarasib, RG6330) is a potent, selective, covalent and orally available KRAS G12C inhibitor with HTRF IC50 of 2.9 pM. |
PC-73313 |
MRTX 0902
SOS1 inhibitor
|
MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK). |
PC-73069 |
Sotorasib
KRAS G12C inhibitor
|
Sotorasib (AMG510) is a potent, selective, covalent KRAS G12C inhibitor with p-ERK IC50 of 68 nM. |
PC-73005 |
TH-Z835
KRAS G12D inhibitor
|
TH-Z835 is a potent, mutant selective KRAS (G12D) inhibitor with IC50 of 1.6 uM. |