| Cat. No. |
Product Name |
Information |
| PC-38331 |
Ras binder 2C07
|
Ras binder 2C07 is a switch-II binding ligand which binds Ras GDP and GTP states.. |
| PC-38328 |
KRpep-2d
|
KRpep-2d (Ac-RRCPLYISYDPVCRR-NH2) is a potent, selective, cell-membrane permeable, cyclic peptide inhibitor of K-Ras(G12D) with IC50 of 1.6 nM, >10-fold selectivity over WT and G12C KRas. |
| PC-36140 |
KRAS inhibitor 11
|
KRAS inhibitor 11 is a first-in-class, high-affinity, noncovalent allosteric KRAS inhibitor, disrupts KRAS-Raf interaction with Kd of 1.2 uM. |
| PC-36032 |
(S)-BAY-293
|
(S)-BAY-293 (BAY293 S-enantiomer) is the S-enantiomer of BAY-293 as a negative control compound.. |
| PC-36031 |
BAY-293 racemate
|
BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM).. |
| PC-35953 |
KRAS G12C inhibitor 11
|
KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 5 nM. |
| PC-35921 |
RAS activator compound 1
|
RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM. |
| PC-35878 |
KRAS-G12C inhibitor 13
|
KRAS-G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays. |
| PC-35765 |
KRAS4b-PDEδ stablizer C19
|
KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells. |
| PC-35594 |
KRAS inhibitor C6ME
|
KRAS inhibitor C6ME is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V in vitro.. |
| PC-35593 |
KRAS inhibitor Cmpd2
|
KRAS inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro. |
| PC-35587 |
RAS inhibitor Abd-7
|
RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signalling. |
