Cat. No. |
Product Name |
Information |
PC-49781 |
MC0704
STAT3 inhibitor
|
MC0704 (MC-0704) is a novel synthetic STAT3 pathway inhibitor, exhibits potential antitumor activity in vitro and in vivo models in docetaxel-resistant TNBC cells. |
PC-49596 |
SOST inhibitor S6
Sclerostin inhibitor
|
SOST inhibitor S6 is a small-molecule targeting Sclerostin (SOST), blocks STAT3 binding to SOST, inhibits breast cancer bone metastasis. |
PC-47050 |
LLL12B
STAT3 inhibitor
|
LLL12B is a selective STAT3 inhibitor that suppresses Th17 development, specifically inhibits STAT3 and suppresses Th17 differentiation and expansion. |
PC-38756 |
pan-IFN inhibitor 5k
Interferon inhibitor
|
pan-IFN inhibitor 5k is a potent and selective inhibitor of interferon-induced JAK-STAT signalling, blocks IFNγ activation of JAK-STAT signalling, also inhibits type I and III IFN-induced STAT phosphorylation in vitro. |
PC-38627 |
STAT3 inhibitor N4
STAT3 inhibitor
|
STAT3 inhibitor N4 is a small molecule capable of inhibiting the STAT3 SH2 domain with IC50 of 0.57 uM, SPR KD of 1.04 uM, inhibits STAT3 dimerization and transcription in vitro and suppresses pancreatic cancer in vivo. |
PC-73110 |
SI-109
STAT3 inhibitor
|
SI-109 (SI 109) is a selective, high-affinity and cell-permeable STAT3 SH2 domain inhibitor with Ki of 9 nM, component of STAT3 degrader SD-36 (PROTAC). |
PC-72002 |
Stat3 inhibitor H182
STAT3 inhibitor
|
Stat3 inhibitor H182 is a potent, selective STAT3 inhibitor, inhibits Stat3 DNA-binding activity with IC50 of 0.66 uM. |
PC-63206 |
KI16
|
KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function, interacts with the STAT3 SH2 domain. |
PC-63081 |
PG-S3-001
|
PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance. |
PC-62863 |
NSC 368262
|
NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers. |
PC-62576 |
QD 232
|
QD 232 is a novel quinazolinedione-based redox modulator that potently inhibits Src/FAK and STAT3 phosphorylation, decreasing pancreatic cancer cell viability and migration. |
PC-62521 |
NSC 311068
|
NSC 311068 is a small molecule that directly tragets and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |