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Azoffluxin

Chemical Structure : Azoffluxin

CAS No.: 2883514-82-5

Azoffluxin (CMLD012336)

Catalog No.: PC-72457Not For Human Use, Lab Use Only.

Azoffluxin (CMLD012336) is a bis-benzodioxolylindolinone that synergizes with fluconazole against C. auris through the inhibition of efflux pump Cdr1, thus increasing intracellular fluconazole levels.

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    Biological Activity

    Azoffluxin (CMLD012336) is a bis-benzodioxolylindolinone that synergizes with fluconazole against C. auris through the inhibition of efflux pump Cdr1, thus increasing intracellular fluconazole levels.
    Azoffluxin increases intracellular accumulation of fluconazole (FLC) by inhibiting Cdr1-mediated efflux in C. auris.
    Azoffluxin potentiates intracellular acting compounds against C. auris, to a similar degree as deletion of CDR1.
    Azoffluxin is active against diverse C. auris strains, azoffluxin potentiated fluconazole in multiple isolates from three of the four major clades. The clade III isolates from South Africa were the exception.
    Azoffluxin enhances fluconazole (FLC) activity against azole-resistant C. albicans isolates.
    Azoffluxin not only enhanced fluconazole activity but also reduced fungal burden by ~1000-fold as a single agent in mice infected with drug-resistant C. auris.

    Physicochemical Properties

    M.Wt 619.642
    Formula C34H34FNO9
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-fluoro-3,3-bis(6-(((R)-2-hydroxy-4-methylpent-4-en-1-yl)oxy)benzo[d][1,3]dioxol-5-yl)indolin-2-one

    References

    1. Kali R Iyer, et al. Nat Commun. 2020 Dec 22;11(1):6429.

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