| Cat. No. |
Product Name |
Information |
| PC-21486 |
EN171
14-3-3 modulator
|
EN171 is 14-3-3 molecular glue that covalently targets 14-3-3 to enhance 14-3-3 interactions with ERa (EC50=9 uM), YAP, and TAZ, impairs estrogen receptor and Hippo pathway transcriptional activity. |
| PC-38502 |
HS-1793
14-3-3 inhibitor
|
HS-1793 is a resveratrol derivative that overcomes the resistance conferred by Bcl-2 in U937 cells via 14-3-3, exhibits antitumor activity via Bad and marked downregulates 14-3-3 protein. |
| PC-72267 |
CU7218
14-3-3 inhibitor
|
CU7218 is a small-molecule inhibitor of 14-3-3 protein, inhibits the interaction between 9J10 and 14-3-3. |
| PC-62030 |
FOBISIN101
14-3-3 inhibitor
|
FOBISIN101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. |
| PC-61238 |
RB-011
14-3-3 inhibitor
|
RB-011 is a small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells. |
| PC-61233 |
Fusicoccin-A
14-3-3 modulator
|
Fusicoccin-A is a small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1. |
| PC-61232 |
Difopein
14-3-3 inhibitor
|
Difopein is a specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity. |
| PC-61231 |
14-3-3 inhibitor BV02
14-3-3 inhibitor
|
14-3-3 inhibitor BV02 is a novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. |
| PC-24500 |
ChREBPα-14-3-3 PPI stabilizer 43
ChREBPα stabilizer
|
ChREBPα/14-3-3 PPI stabilizer 43 is a potent, specific molecular glue as ChREBPα/14-3-3 protein-protein interaction (PPI) stabilizer with EC50 of 3.8 uM, protect human β-cells from glucolipotoxicity. |
| PC-23288 |
UTKO1
14-3-3 inhibitor
|
UTKO1 is a cell migration inhibitor targeting 14-3-3ζ, also is a selective small molecule inhibitor of notochord tubulogenesis, binds directly and selectively to Ciona 14-3-3εa. |
| PC-22228 |
At14-3-3 inhibitor 2
14-3-3 inhibitor
|
At14-3-3 inhibitor 2 is a covalent selective inhibitor for Arabidopsis thaliana 14-3-3 protein (At14-3-3), potently inhibits the interaction between At14-3-3 Lambda and FAM-FD with IC50 of 1.2 uM. |
| PC-21138 |
14-3-3σ/ERα stabilizer 181
14-3-3σ/ERα stabilizer
|
14-3-3σ/ERα stabilizer 181 is a selective and highly potent covalent stabilizer of 14-3-3σ/ERα PPI complex with EC50 of 1 uM. |
