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Cat. No. Product Name Information
PC-49806

5-HT2A agonist (R)-70

5-HT2A agonist

5-HT2A agonist (R)-70 is a potent selective 5-HT2A receptor partial agonist with EC50 of 110 nM in calcium flux assays, and Ki value of 880 nM.
PC-49805

5-HT2A agonist (R)-69

5-HT2A agonist

5-HT2A agonist (R)-69 is a potent selective 5-HT2A receptor partial agonist with EC50 of 41 nM in calcium flux assays, and Ki value of 680 nM.
PC-49161

AS2030680

5-HT5A antagonist

AS2030680 is a potent, selective and brain-penetrating 5-HT5A receptor antagonist with Ki of 0.58, 1.1 and 2.6 nM against human, rat, mouse 5-HT5A receptors, respectively.
PC-49006

LY344864

5-HT1F agonist

LY344864 is a potent, selective agonist of 5-HT1F receptor with Ki value of 6 nM, with little to no affinity for other serotonergic and non-serotonergic neuronal binding sites.
PC-47113

TZB-30878

5-HT1A agonist/5-HT3 antagonist

TZB-30878 is a potent, selective, orally bioavailable 5-HT1A agonist and 5-HT3 antagonist, selectively binds to human 5-HT1A and 5-HT) receptors with Kd values of 0.68 and 8.90 nM, respectively.
PC-47112

CSTI-300

5-HT3 agonist

CSTI-300 (SMP-100) is a potent, selective 5-HT3 receptor partial agonist with high affinity for human and rat 5-HT3 receptor (Ki=2.0 nM).
PC-38716

SB-699551

5-HT5A antagonist

SB699551 is a potent, selective 5-HT5A receptor antagonist with pKi of 8.3, >100-fold selectivity over 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors.
PC-73308

NLX-101

5-HT1A agonist

NLX-101 (F15599) is a potent, highly selective post-synaptic 5-HT1A receptor agonist with Ki of 3.4 nM.
PC-38060

SB 204741

5-HT2B antagonist

SB 204741 is a potent and selective 5-HT2B receptor antagonist (pA2=7.95).
PC-43515

SB 242084

5-HT2C antagonist

SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist with pKi of 9.0, 100- and 158-fold selectivity over the closely related 5-HT2B and 5-HT2A subtypes.
PC-35004

PF-05212377

5-HT6 antagonist

PF-05212377 (SAM-760, PF 5212377) is a potent and selective 5-HT6 receptor antagonist with Ki of 0.32 nM (human 5HT6), shows potential therapy for the symptomatic treatment of mild to moderate Alzheimer's disease.
PC-63486

SB 258585 hydrochloride

5-HT6 antagonist

SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes.

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