| Cat. No. |
Product Name |
Information |
| PC-49355 |
ALM301
|
ALM301 is a potent, selective and allosteric inhibitor of AKT1 and AKT2 with IC50 of 125 nM and 95 nM respectively. |
| PC-49017 |
Ipatasertib
|
Ipatasertib (GDC-0068) is a potent, selective, orally bioavailable pan-Akt inhibitor with IC50 values of 5 nM, 18 nM, and 8 nM for Akt1, Akt2, and Akt3, respectively. |
| PC-38198 |
TAS0612
|
TAS0612 (TAS-0612) is an orally bioavailable multikinase inhibitor of AKT, p70S6K, and p90RSK, inhibits Y-box-binding protein (YBX1) phosphorylation. |
| PC-36126 |
Borussertib
|
Borussertib is a potent, first-in-class, covalent-allosteric AKT inhibitor with IC50 of 0.8 nM and Ki of 2.2 nM for WT Akt. |
| PC-43433 |
A-674563
|
A-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1). |
| PC-61416 |
LY2780301
|
LY2780301 is a potent, highly selective, ATP-competitive dual inhibitor of p70S6K and Akt under development for the treatment of solid tumours and non-Hodgkin's lymphoma. |
| PC-45548 |
SC-79
|
SC-79 is a unique specific Akt activator, binds to the PH domain of Akt and inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol. |
