| Cat. No. |
Product Name |
Information |
| PC-49050 |
AGF94
|
AGF94 is a 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate with potent antiproliferative activities against tumor cells, with proton-coupled folate transporter (PCFR) and folate receptor (FR) selectivity over the reduced folate carrier (FRC), inhibtis de novo purine nucleotide biosynthesis. |
| PC-49049 |
AGF154
|
AGF154 is a 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate with potent antiproliferative activities against tumor cells, with proton-coupled folate transporter (PCFR) and folate receptor (FR) selectivity over the reduced folate carrier (FRC), inhibtis de novo purine nucleotide biosynthesis. |
| PC-49048 |
ONX0801
|
ONX 0801 (Idetrexed, CT900, BGC 945) is a small molecule thymidylate synthase (TS) inhibitor, can be selectively transported to tumor cells via α-folate receptor (α-FR, KD=1 nM), but not the physiological reduced-folate carrier system (RFC). |
| PC-49047 |
Plevitrexed
|
Plevitrexed (ZD 9331, BGC 9331)a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM, selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, causes DNA synthesis inhibition and apoptosis. |
| PC-47090 |
TH7299
|
TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM. |
| PC-73018 |
DS18561882
|
DS18561882 (DS 18561882, DS18) is a potent, isozyme-selective, orally available MTHFD2 inhibitor with IC50 of 6.3 nM, >800-fold selectivity over MTHFD1. |
| PC-73015 |
DS44960156
|
DS44960156 (DS 44960156) is a isozyme-selective MTHFD2 inhibitor with IC50 of 1.6 uM, without inhibitory effect against MTHFD1 (IC50>30 uM). |
