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Cat. No. Product Name Information
PC-22708

Necrox-7

HMGB1 inhibitor, Necrosis inhibitor

NecroX-7 (NecX, NecroX 7) is a small molecule necrosis inhibitor by inhibiting high-mobility group box 1 protein (HMGB1) release.
PC-21095

EGCG

Anticancer

EGCG (Epigallocatechin-3-gallate) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis, inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity.
PC-20272

ANP0903

ANP0903 is an analog of HIV-1 protease inhibitor darunavir, induces cytotoxicity in hepatocellular carcinoma cell lines, triggers apoptosis by enhancing ER stress.
PC-47089

Tpz-1

PCD inducer

Tpz-1 is a unique cytotoxic compound that elicits potent and selective programmed cell death in human blood, breast, colon, and cervical cancer cell lines, interferes with components of signaling pathways and the cytoskeleton that are important to cell shape, internal organization, growth, and division.
PC-38741

WZY-321

XAF1 inhibitor

WZY-321 a small molecule glioma cell apoptosis inducer, binds to XAF1 3-UTR and decreases XAF1 (X-linked inhibitor of apoptosis-associated factor 1) mRNA levels.
PC-38723

Devimistat

KGDH inhibitor, PDK activator

CPI-613 (Devimistat) is an antimitochondrial metabolism agent that specifically induces inactivating phosphorylation of tumor cell PDH via stimulation of PDKs 1 to 4, inhibits KGDH function strongly and rapidly, selectively in tumor cells.
PC-73048

Leusin-1

ALL G2 phase inhibitor

Leusin-1 (Leukemia specific inhibitor 1) is a cell cycle phase specific inhibitor that specifically arrest leukemia cells during G2-phase and triggers an apoptotic cell death (CCRF-CEM IC50= 2.66 uM and TOM1 IC50= 0.877 uM).
PC-72413

WEHI-7326

Mitotic inhibitor

WEHI-7326 (WEHI 7326) is a specific mitotic inhibitor and potential anticancer agent, causes cell cycle arrest in G2/M, cell death in vitro (MDA-MB-231 IC50=24.4 nM), and displays efficacious anti-tumor activity in vivo.
PC-36025

CCI-007

Apoptosis inducer

CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485.
PC-63230

NSC 745887

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways.
PC-45496

Apoptosis Activator 2

Apoptosis activator

Apoptosis Activator 2 is an apoptosis activator that strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation, leads to the destruction of cells (Apaf-1 dependent) with IC50 of 4 uM.
PC-42276

JPH203

LAT1 inhibitor

Nanvuranlat (JPH203, KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2.

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