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Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-22101

IITR08367

Efflux pump AbaF inhibitor

IITR08367 is a potent efflux inhibitor against AbaF in A. baumannii, inhibits efflux pumps by disrupting the proton gradient across the bacterial membrane.
PC-20744

MAC13772

Biotin biosynthesis inhibitor

MAC13772 is a small molecule inhibitor of bacterial enzyme BioA with IC50 of 250 nM, the antepenultimate step in biotin biosynthesis, MAC13772 inhibits biotin biosynthesis.
PC-20706

Durlobactam sodium

Beta-lactamase inhibitor

Durlobactam (ETX2514) sodium is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively.
PC-20570

ML328

Bacterial AddAB complex inhibitor

ML328 is a first-in-class, dual inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC50 of 15.7 and 4.8 uM, respectively.
PC-20073

TBI-223

Antibiotic

TBI-223 is an oxazolidinone with excellent oral bioavailability and activity against Gram-positive bacteria, works as protein synthesis inhibitor, targets an early step involving the binding of N-formylmethionyl-tRNA to the ribosome.
PC-49550

CUO246

DNA Gyrase inhibitor

CUO246 (CUO-246) is a potent, selective bacterial DNA gyrase/topoisomerase IV inhibitor, CUO246 is active in vitro against a broad range of Gram-positive, fastidious Gram-negative, and atypical bacterial pathogens.
PC-49514

TBA-7371

DprE1 inhibitor

TBA-7371 (TBA7371, AZ 7371) is a potent, non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) with IC50 of 10 nM, an enzyme involved in mycobacterial cell wall biogenesis.
PC-49257

JSF-2659

GyrB/ParE inhibitor

JSF-2659 is the orally bioavailable, phosphate prodrug of JSF-2414, JSF-2659 (100 and 250 mg/kg, p.o.) is highly efficacious in reducing microbial burdens in animal models of Neisseria gonorrhoeae vaginal infection as well as VRSA and C. difficile-induced colitis models.
PC-49256

JSF-2414

GyrB/ParE inhibitor

JSF-2414 (JSF2414) is a potent, small molecule GyrB/ParE dual binding inhibitor, simultaneously binds to ATP binding regions of DNA gyrase (GyrB) and topoisomerase (ParE) and displays potent in vitro activity against strains of MRSA, VRSA and VISA.
PC-49186

SF235

Mip inhibitor

SF235 is a small-molecule inhibitor of macrophage infectivity potentiator (Mip) protein with IC50 and Ki 0.42 and 0.29 uM against B. pseudomallei Mip (BpMip) peptidyl-prolyl cis/trans isomerase (PPIase) activity, reduce B. pseudomallei virulence in vitro.
PC-49180

BDM71339

EthR inhibitor

BDM71339 is the first small molecule inhibitor of mycobacterial transcriptional regulator EthR, boosts ten times the activity of ethionamide in TB-infected macrophages at low nanomolar concentrations (EC50=72 nM) in vitro.
PC-49179

BVL-GSK098

VirS inhibitor

BVL-GSK098 (Alpibectir) is a small molecule able to inhibit Mycobacterium tuberculosis transcription regulator VirS, boosts bioactivation of ethionamide (ETH) and lower ETH MIC.

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