| Cat. No. |
Product Name |
Information |
| PC-38808 |
CCT369260
|
CCT369260 is a highly potent, orally active BCL6 degrader with DC50 of 54 nM in cellular BCL6 degradation assays. |
| PC-73236 |
ZH07
|
ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24) is a potent, selective dual Mcl-1 and Bfl-1 inhibitor, binds both Mcl-1 and Bfl-1 with Ki of 97 nM and 100 nM, respectively. |
| PC-72944 |
BTSA1
|
BTSA1 (BAX Trigger Site Activator 1) is a potent, selective, orally bioavailable BAX trigger site activator, binds with high affinity (EC50=144 nM) and specificity to the N-terminal activation site. |
| PC-72943 |
BTSA1.2
|
BTSA1.2 is a potent, selective, orally bioavailable BAX activator, demonstrated increased binding to BAX (IC50=149 nM) compared to BTSA1 (IC50=247 nM). |
| PC-72541 |
BFL-1 inhibitor 4E14
|
4E14 (BFL-1 BH3 inhibitor 4E14) is a potent, covalent BFL-1 (BCL2A1 or A1) inhibitor that disrupt BH3-binding activity with IC50 of 23 nM (FITC-BID BH3/BFL-1 interaction). |
| PC-72311 |
Lisaftoclax
|
Lisaftoclax (APG-2575) is a novel BCL-2 selective inhibitor with binding Ki of < 0.1/0.1 nM for Bcl-2/Bcl-XL, no binding affinity against BCL-W/MCL-1. |
| PC-72240 |
BAX inhibitor BAI1
|
BAX inhibitor BAI1 (BAI1) is a small-molecule allosteric inhibitor of BAX, bind directly to BAX and inhibits tBID-induced BAX-mediated membrane permeabilization with IC50 of 3.4 uM. |
