| Cat. No. |
Product Name |
Information |
| PC-23130 |
WK692
BCL6 inhibitor
|
WK692 is a specific small molecule BCL6 inhibitor, directly binds to BCL6 BTB domain (SPR, KD=324 nM), disrupts BCL6BTB/SMRT interaction (IC50=16 nM) and activates the expression of BCL6 downstream genes in cancer cells. |
| PC-21675 |
Sonrotoclax
Bcl-2 inhibitor
|
Sonrotoclax (BGB-11417) is a potent, selective and second-generation BCL2 inhibitor with IC50 of 0.014 nM and SPR KD value of 0.046 nM, overcomes BCL2 G101V mutation-induced venetoclax resistance. |
| PC-21609 |
WK369
BCL6-BTB inhibitor
|
WK369 (WK-369) is a specific small molecule inhibitor of BCL6, directly binds to the BCL6-BTB domain (SPR KD=2.24 uM) and blocks the interaction between BCL6 and SMRT with IC50 of 0.32 uM in HTRF assays. |
| PC-21258 |
M109S
Bax inhibitor
|
M109S is a small molecule protecting cells from mitochondria-dependent apoptosis wtih EC50 of 23.4 nM in iBax cells, directly interacts with Bax (Kd=153 nM, MST assay) and inhibits Bax activation. |
| PC-20689 |
BAU-243
Bcl-2 inhibitor
|
BAU-243 (BAU243) is a novel BH3 mimetic Bcl-2 inhibitor with a high affinity, effectively reduces overall GBM cell proliferation including a subpopulation of cancer-initiating cells. |
| PC-20511 |
ABBV-167
BCL-2 inhibitor
|
ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax (Cat. PC-49764), shows significantly increased water solubility to venetoclax, demonstrates a lower food effect with respect to venetoclax. |
| PC-20503 |
CCT374705
BCL6 inhibitor
|
CCT374705 is a potent, selective, in-vivo active BCL6 inhibitor with TR-FRET IC50 of 6 nM. |
| PC-20245 |
CGDF-190-20
BFL-1 inhibitor
|
CGDF-190-20 is a selective small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 365 nM in FP assays. |
| PC-20244 |
CGDF-183-20
BFL-1 inhibitor
|
CGDF-183-20 is a selective small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 264 nM in FP assays. |
| PC-20243 |
BDM53787
BFL-1 inhibitor
|
BDM53787 is a selective small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 0.8 uM (inhibition FITC–Bim BH3 binding to Bfl-1). |
| PC-20242 |
BDM49234
BFL-1 inhibitor
|
BDM49234 is a selective small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 6.3 uM (inhibition FITC–Bim BH3 binding to Bfl-1). |
| PC-20241 |
BDM44898
BFL-1 inhibitor
|
BDM44898 is a small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 1.6 uM. |
