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Cat. No. Product Name Information
PC-22395

Tafbromin

TAF1(2) inhibitor

Tafbromin is a selective inhibitor of TAF1 bromodomain by binding to the second bromodomain (TAF1(2)) with KD of 260 nM, inhibits Hh pathway-dependent osteoblast differentiation.
PC-21341

PFI-6

MLLT1/3 ligand

PFI-6 is a selective small-molecule chemical probe inhibitor for the YEATS domain of MLLT1 and MLLT3 with IC50 of 140 nM and 160 nM, respectively.
PC-20573

Birabresib

BET bromodomain inhibitor

Birabresib (OTX-015) is a potent, competitive inhibitor of BET bromodomain BRD2, BRD3, and BRD4 with EC50 of 10-19 nM, inhibits binding of BRD2, BRD3, and BRD4 to acetylated histone H4 (AcH4) with IC50 of 92-112 nM.
PC-20463

BI 1702135

SMARCA2 binder

BI 1702135 (Compound 4) is a potent SMARCA2 binder for targeted protein degradation (PROTAC) design as BI 1810284 (ACBI2, Cat. PC-20464).
PC-20343

FHT-2344

BRG1/BRM inhibitor

FHT-2344 (FHT2344) is a potent, selective inhibitor of SMARCA4 and SMARCA2 (BRG1 and BRM) with IC50 of 26 and 13 nM respectively, the ATPase component of the BAF complex.
PC-20342

FHT-1015

BRG1/BRM inhibitor

FHT-1015 (FHT1015) is a potent, selective inhibitor of SMARCA4 and SMARCA2 (BRG1 and BRM) with IC50 of 4 and 5 nM respectively, the ATPase component of the BAF complex.
PC-20312

SJ1461

BET inhibitor

SJ1461 (SJ-1461) is a potent and orally bioavailable BET inhibitor with IC50 of 6.8/0.2 nM for BRD4 BD1/BD2, and 1.3/0.1 nM for BRD2 BD1/BD2, respectively.
PC-20181

XS018661

ENL/AF9 YEATS inhibitor

XS018661 (XS 018661) is a potent first-in-class inhibitor of the YEATS domains of ENL and AF9 with Kd of 754/523 nM, IC50 of 1.6/3.0 uM, respectively.
PC-20178

L-Moses dihydrochloride

PCAF/KAT2B inhibitor

L-Moses dihydrochloride (L-45) is a potent, selective, and cell-active PCAF (KAT2B) bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4.
PC-20163

CG223

BET inhibitor

CG223 (CG14223) is a potent and specific inhibitor of BET proteins with Kd of 45 nM for the C-terminal bromodomain of BRD3 (i.e. BRD3(2)) to 370 nM for the N-terminal bromodomain of BRDT (i.e. BRDT(1)).
PC-20162

I-BET282

BET inhibitor

I-BET282 is a potent and selective pan-inhibitor of bromodomain and extra terminal (BET) proteins with pIC50 of 7.4 for BRD4-BD1, ITC Kd of 47.5 nM for BRD4, shows equivalent potency against BD1 and BD2 domains.
PC-20161

I-BET282E

BET inhibitor

I-BET282E (I-BET282 mesylate) is the mesylate salt of I-BET282, I-BET282 is a potent and selective pan-inhibitor of bromodomain and extra terminal (BET) proteins.

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