| Cat. No. |
Product Name |
Information |
| PC-49366 |
iBRD4-BD1
|
iBRD4-BD1 is a potent, selective inhibitor of the first BRD4 bromodomain with IC50 of 12 nM, shows 23- to 6200-fold intra-BET selectivity. |
| PC-49210 |
GNE-064
|
GNE-064 (GNE064) is a potent, selective, and orally bioavailable inhibitor of the bromodomains of SMARCA2 (BRM), SMARCA4 (BRG1) and PBRM1 (polybromo-1) bromodomain 5 (PBRM1(5)) with IC50 of 10 nM, 16 nM and 18 nM, respectively. |
| PC-49079 |
RVX-208
|
Apabetalone (RVX-208) is a potent, selective inhibitor of second BET bromodomains (BD2) with IC50 of 0.51 uM, 170-fold selectivity over BD1 (IC50=87 uM). |
| PC-73385 |
SRX3305
|
SRX3305 is a potent, triple BTK/PI3K/BRD4 inhibitor with IC50 of 6.5 nM, 15 nM, and 4 nM toward BTK, PI3Kɑ and PI3Kδ respectively, inhibits BRD4 BD1 and BD2 with IC50 of 77 and 95 nM. |
| PC-73384 |
SRX3262
|
SRX3262 (SRX 3262, SRX 3262) is a potent, triple action BTK, PI3K and BRD4 inhibitor with potency against BTK (IC50=35 nM), PI3Kδ (IC50=16 nM), PI3Kα (IC50=64 nM), and both bromodomains of BRD4 (IC50 BD1=228 nM, IC50 BD2=348 nM). |
| PC-73383 |
SRX3177
|
SRX3177 is a potent, triple BRD4/PI3K/CDK4/6 inhibitor with nanomolar potency against PI3Kα (IC50=79 nM), BRD4 bromodomains (BD1 and BD2) (IC50=33 nM and 89 nM, respectively), and CDK4/6 (IC50=2.5/3.3 nM). |
| PC-73382 |
SRX3212
|
SRX3212 (SRX 3212) is a potent, dual BRD4/PI3Kα inhibitor with IC50 of 3.7 nM (BRD4 BD1) and 32 nM (BRD4 BD2), IC50 of 22 nM for PI3Kα. |
