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Cat. No. Product Name Information
PC-49187

GLPG2451

GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation.
PC-72975

Bamocaftor

Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function.
PC-72974

Bamocaftor potassium

Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function.
PC-38208

ARN23765

ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays.
PC-43442

VX-809

VX-809 (Lumacaftor, VRT 826809) is a potent CFTR corrector that increases F508del-CFTR-mediated chloride transport amd improves F508del-CFTR maturation in FRT cells with EC50 of 0.1 and 0.5 uM, respectively.
PC-43325

Ivacaftor

Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM.
PC-60652

Corr4A

Corr4A is a small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM.

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