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Cat. No. Product Name Information
PC-20491

VX-661

CFTR corrector

Tezacaftor (VX-661) is a broad-acting CFTR corrector that facilitates the cellular processing and trafficking of normal CFTR and multiple mutant CFTR forms, including F508del, thereby increasing the amount of CFTR protein at the cell surface, resulting in increased chloride transport.
PC-49187

GLPG2451

F508del CFTR potentiator

GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation.
PC-38707

ABBV-3221

CFTR corrector

ABBV-3221 (GLPG-3221) is a highly potent CFTR corrector with HBE-TECC EC50 of 105 nM.
PC-38357

Dirocaftor

CFTR potentiator

Dirocaftor (PTI-808) is a potent small molecule CFTR potentiator that enhances the function of CFTR protein by opening chloride channels, shows potential for treatment of of cystic fibrosis (CF).
PC-73453

Vanzacaftor

CFTR corrector

Vanzacaftor (VX-121) is a potent, selective cystic fibrosis transmembrane regulator (CFTR) corrector, with potential for treatment of cystic fibrosis.
PC-73345

SRI-41315

eRF1 degrader

SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.
PC-73172

Elexacaftor

CFTR corrector

Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector and modulator for cystic fibrosis treatment.
PC-72975

Bamocaftor

CFTR corrector

Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function.
PC-72974

Bamocaftor potassium

CFTR corrector

Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function.
PC-72256

CP-628006

CFTR potentiator

CP-628006 (CP628006) is a small molecule CFTR potentiator, potentiates low temperature-rescued F508del-CFTR with EC50 of 0.4 uM.
PC-38208

ARN23765

CFTR corrector

ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays.
PC-35461

Olacaftor

CFTR corrector

Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, shows the potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis.

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