| Cat. No. |
Product Name |
Information |
| PC-49187 |
GLPG2451
|
GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation. |
| PC-72975 |
Bamocaftor
|
Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function. |
| PC-72974 |
Bamocaftor potassium
|
Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function. |
| PC-38208 |
ARN23765
|
ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays. |
| PC-43442 |
VX-809
|
VX-809 (Lumacaftor, VRT 826809) is a potent CFTR corrector that increases F508del-CFTR-mediated chloride transport amd improves F508del-CFTR maturation in FRT cells with EC50 of 0.1 and 0.5 uM, respectively. |
| PC-43325 |
Ivacaftor
|
Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. |
| PC-60652 |
Corr4A
|
Corr4A is a small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM. |
