| Cat. No. |
Product Name |
Information |
| PC-49187 |
GLPG2451
|
GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation. |
| PC-72975 |
Bamocaftor
|
Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function. |
| PC-72974 |
Bamocaftor potassium
|
Bamocaftor (VX-659) is a next-generation CFTR corrector, restores F508del-CFTR protein function. |
| PC-38208 |
ARN23765
|
ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays. |
| PC-60232 |
GLPG-1837
|
A potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively. |
| PC-60231 |
GLPG-2222
|
GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM. |
| PC-20491 |
VX-661
|
Tezacaftor (VX-661) is a broad-acting CFTR corrector that facilitates the cellular processing and trafficking of normal CFTR and multiple mutant CFTR forms, including F508del, thereby increasing the amount of CFTR protein at the cell surface, resulting in increased chloride transport. |
