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Cytomegalovirus (CMV) is a betaherpesvirus with a 50 to 90% prevalence frequency in the adult human population. It is an opportunistic pathogen controlled largely by the immune system, especially cell-mediated immunity. Clinically serious disease occurs primarily in three situations involving deficient immune systems.

Treatment of HCMV disease is limited to relatively toxic drugs with that target viral DNA synthesis. The most commonly used HCMV drug, ganciclovir, is a nucleoside prodrug phosphorylated by the viral UL97 kinase to the nucleotide analog form and is selectively incorporated into progeny DNA by the HCMV UL54-encoded DNA polymerase. Foscarnet is a pyrophosphate analog. Effective concentrations of foscarnet are much higher than that of ganciclovir. Both of these drugs are nephrotoxic; ganciclovir also causes neutropenia and is teratogenic. Cidofovir is a nucleoside phosphonate that is severely renal toxic.


Cat. No. Product Name Information


Antiviral agent

NPP-669 (NPP669) is an orally bioavailable cidofovir (CDV) analogue and prodrug, has increased lipophilicity, improved oral absorption, reduced nephrotoxicity, increased cellular uptake, and increased activity against several dsDNA viruses compared to CDV.


Adenoviruse inhibitor

JMX0493 is a potent inhibitor of human adenoviruse (HAdV) infection with IC50 of 0.78 uM (HAdV-5), targets HAdV entry pathway and prevents viral particle disassembly and subsequent release from the endosome.


CMV pUL97 inhibitor

Maribavir (1263W94, Benzimidavir) is a potent and selective inhibitor of human cytomegalovirus (HCMV) replication with IC50 of 0.13 uM against laboratory strain AD169, and 0.03-0.13 uM against 10 clinical HCMV isolates.


HCMV inhibitor

CFI02 (CFI-02) is a specific inhibitor of human cytomegalovirus (HCMV) glycoprotein B-mediated fusion with IC50 of 40 nM against laboratory adapted HCMV strain AD169.


Brincidofovir (CMX 001, Cidofovir HDP) is a lipid conjugate of the acyclic nucleotide phosphonate, cidofovir that shows activity against all five families of dsDNA viruses that cause human morbidity and mortality, including orthopoxviruses such as variola virus, the cause of human smallpox.


Tomeglovir (BAY 384766) is a potent, highly selective, nonnucleoside inhibitor of cytomegalovirus (CMV) replication.

HCMV NEC inhibitor GK1

HCMV NEC inhibitor

HCMV NEC inhibitor GK1 is a small molecule inhibitor of HCMV nuclear egress complex (NEC) subunit interactions, interferes with the interaction of UL50 and UL53 with IC50 of 5.3 uM in HTRF assays, exerts selective antiviral activity.

HHV protease inhibitor 43

HHV protease inhibitor

HHV protease inhibitor 43 is an irreversible small molecule inhibitor of human herpesvirus (HHV) protease targeting a non-catalytic cysteine (C161) with IC50 of 4 uM (HCMV), exhibits broad-spectrum inhibition of other HHV protease homologs.


CMV inhibitor

Letermovir (AIC246) is a potent anti-cytomegalovirus (CMV) compound, exhibits very potent in vitro antiviral activity aginst different HCMV laboratory strains (EC50=3-5 nM), through a specific antiviral mechanism that involves the viral terminase.

GW 275175X

GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation.


BDCRB (GW 275175) is a potent and selective inhibitor of human CMV replication by blocking the processing and maturation of viral DNA..

Cidofovir dihydrate

The prodrug of cidofovir diphosphate that inhibits cytomegalovirus (CMV) viral replication by selectively inhibiting viral DNA polymerases.

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